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临床试验/NCT03556111
NCT03556111Unknown不适用

Patient Satisfaction and Bone Gain Following Autogenous Particulate Sticky Bone Preparation With Xenograft Versus Without Xenograft for Grafting of Maxillary Anterior Knife-edge Ridge in Partially Edentulous Patients for Implant Placement

Cairo University1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2018年7月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
12
试验地点
1
主要终点
Patient satisfaction

研究概览

简要总结

The aim is to evaluate the value and efficiency of sticky bone in the augmentation of alveolar ridge deficiency when being used with or without xenogenic bone graft for esthetic implant placement.

详细描述

Modern Dentistry aims to restore what is missing, no matter what the difficulty is. As many patients have lost their teeth to a number of factors, either trauma or disease or lack of care. Now the individuals are seeking to restore the function and esthetics. The more the number of teeth is missing along with ridge deficiencies can present serious challenges to the clinician.

Implant supported prosthesis is an attractive option for restoring edentulous or partially edentulous patients. However, extensive loss of the alveolar bone is a complex problem that faces many surgeons. This era has witnessed numerous trials and research for bone augmentation for the defective alveolar ridge. The goal is to create sufficient space for endosseous implant placement in a knife edge ridge.

Alveolar bone resorption occurs in either a horizontal or vertical direction. It can also be composite. There are 3 classes of bone-grafting materials based upon the mode of action. Autogenous bone is an organic material and forms bone by osteogenesis, osteoinduction, and osteoconduction.

Allografts such as demineralized freeze-dried bone are osteoinductive and osteoconductive and may be cortical and/or trabecular in nature.

Alloplasts such as hydroxyapatite and tricalcium phosphate may be synthetic or natural, vary in size, and are only osteoconductive. They can be divided into three types based upon the porosity of the product and include dense, macroporous, and microporous materials. In addition, alloplastic materials may be crystalline or amorphous. These materials have different properties and therefore indications.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
18 Years 至 48 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • - Alveolar bone width 3mm or less in anterior maxillary knife edge ridge as evaluated preoperatively on the CBCT
  • Both sexes.
  • Good oral hygiene.
  • Age between 18 and 48 years. Highly motivated patients

排除标准

  • - Patient with Bad oral hygiene
  • Post-menopausal females with osteoporosis
  • Patient with uncontrolled systemic disease For instance: uncontrolled Diabetes Mellitus

研究组 & 干预措施

anterior knife-edge maxilla graft (Without Xenograft Usage)

Experimental

The intervention will be a Sticky bone augmentation of defect. It is prepared using particulate autologous graft only along with fibrin glue and growth factors obtained from the patients' blood.

The sample is withdrawn and placed in plastic tubes which are spun twice in a centrifuge at a certain speed and time. The first spin to obtain the fibrin glue and the second to obtain the growth factors. The mixture is added to the harvested autogenous bone to form a semi-solid bone graft that is easily manipulated in the recipient site.

干预措施: Sticky bone augmentation (Procedure)

anterior knife edge maxilla graft (With Xenograft Usage)

Experimental

The intervention will be the sticky bone augmentation of the defect using both particulate autogenous and xenograft bovine bone.

The bone will be harvested from the donor, coupled with the bovine bone, the growth factors and the fibrin glue that is obtained from the patient's own blood sample.

The venous blood sample is placed in plastic tubes to be centrifuged at a certain speed and time to obtain the fibrin glue and growth factors.

The mixture is prepared until the bone is sticky and ready to be placed in the recipient defective maxilla

干预措施: Sticky bone augmentation (Procedure)

结局指标

主要结局

Patient satisfaction

时间窗: 8 months after bone graft placement

Patient satisfaction with the bone gain and the prosthetic implant placement

次要结局

  • bone width gain(5 month after bone graft placement)
  • Successful implant placement(5 months after bone graft placement)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Nesma Mattar

principle investigator

Cairo University

研究点 (1)

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