A clinical trial to study the effect of a drug, curcumin in patients with periodontitis
- Conditions
- Health Condition 1: K053- Chronic periodontitis
- Registration Number
- CTRI/2019/01/016927
- Lead Sponsor
- Dr Riya Achamma Daniel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
1 Systemically healthy individuals
2 Presence of a minimum of 20 teeth in the oral cavity
3 Localised periodontal pockets with probing depths greater than 4mm i.e., Periodontitis in its stages 2 and 3, as described by the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions, and published by the American Academy of Periodontology (AAP)
1 Known allergy to curcumin and/ or hydroxyl propyl methyl cellulose
2 Systemic diseases and/or Inflammatory conditions, Obesity
3 Former or current tobacco users
4 Chronic consumption of alcohol
5 Use of anti-inflammatory drugs and antibiotics over the past 3 months
6 Periodontal therapy in any form, surgical or non surgical in the past 6 months
7 Pregnant and lactating mothers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evels of interleukin 1 beta in the gingival crevicular fluid quantified by ELISA in picogram per milliliterTimepoint: 1 month from baseline
- Secondary Outcome Measures
Name Time Method Probing pocket depth <br/ ><br>Clinical attachment level <br/ ><br>Gingival index by Loe and Silness in 1963 <br/ ><br>Plaque index by Silness and Loe in 1964 <br/ ><br>Timepoint: 1 month and 3 months from baseline