跳至主要内容
临床试验/NCT04759378
NCT04759378Unknown不适用

Comorbid Disorders of the Esophagus in Patients With Irritable Bowel Disease

Assiut University0 个研究点目标入组 50 人开始时间: 2021年2月25日最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
主要终点
Incidence of GERD in IBS patients who have upper GIT symptoms

研究概览

简要总结

assess the incidence of the entire spectrum of esophageal disorders and possible theories for overlap in IBS patients using different diagnostic modalities.

详细描述

In the practice of a gastroenterologist, irritable bowel syndrome (IBS) is the most frequent functional disorder. Its prevalence in the population is 9.8%-12.8%. Its frequency in women is more than men. In some studies, it has been shown that a patient may have an overlap of symptoms of different functional diseases of the gastrointestinal tract. Different researchers have ambiguously assessed the frequency of occurrence of esophageal disorders in patients with IBS. So, based on the publications of different authors, they are found in 15-80% of cases. In a study by N. de Bortoli et al. (2016) noted the association of IBS with functional heartburn in 77% of cases, and with GERD and hypersensitive esophagus (called heartburn associated with reflux) - in 33% of cases.

Traditionally, diagnostics of a combination of functional disorders of the esophagus and intestines were based on data X-ray and endoscopic methods. However modern research has shown the importance of using in this group of patients with daily combined pH impedance measurement. Thus, many authors have noted the undoubted advantages of this method in the diagnosis of esophageal disorders. Unfortunately, works devoted to this topic, extremely few in number, and the information obtained in them is quite contradictory, which indicates the need to continue research in this direction.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Screening
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Established diagnosis of IBS (according to the Rome criteria of the III revision).
  • Upper GIT symptoms in the form of heartburn (sometimes belching), a lump in the throat, and non-cardiac chest pain.

排除标准

  • History of thoracic, esophageal, or gastric surgery.
  • Presence of duodenal or gastric ulcer on upper endoscopy.
  • Presence of duodenal or gastric cancer on upper endoscopy.
  • Conditions that prevent the installation of a nasogastric tube (nasopharyngeal formation, severe lumen-facial trauma).
  • mental disorders state and disability.
  • Pregnancy and breastfeeding.

结局指标

主要结局

Incidence of GERD in IBS patients who have upper GIT symptoms

时间窗: baseline

use the result of the comprehensive examination, upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS.

Incidence of Functional esophageal disorders in IBS patient who have upper GIT symptoms.

时间窗: baseline

use the result of the comprehensive examination, including upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bishoy Shehata

resident doctor at Assiut Univeristy Hospotal

Assiut University

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