Effect of gum treatment on a acute phase protein and iron indices in periodontitis patients undergoing haemodialysis

Completed

• Conditions: End stage renal disease, Group I - Chronic Periodontitis under hemodialysis for less than a yearGroup II - Chronic Periodontitis under hemodialysis for more than a yearGroup III - Chronic Periodontitis,

• Registration Number: CTRI/2017/12/010727
• Lead Sponsor: Sheethel Menon V

Brief Summary

Chronicperiodontitis, a inflammatory disease of supporting tissues of teeth, is foundto increase the systemic inflammatory burden possibly facilitated by acutephase reactants like C-reactive protein (CRP), which aggravates the existingmetabolic conditions like diabetes, hypertension and anemia in chronic kidneydisease(CKD) patients undergoing haemodialysis

**Aim of the study**

To evaluate effect of non-surgicalperiodontal therapy on clinical, renal and haematological parameters atbaseline and 3 months postoperatively.

**Materials andMethods**

Thiswas a comparative interventional study. Sixty chronic periodontitis patientswere divided into three groups which consisted of CKD patients undergoinghaemodialysis for less than a year (Group I), CKD patients undergoing haemodialysisfor more than a year (Group II) and systemically healthy chronic periodontitispatients(Group III).  Clinical parameterswere recorded at baseline, 1 month and 3 months after nonsurgical periodontaltherapy. C reactive protein (CRP), transferrin saturation (TSAT) and serumferritin was observed at baseline and 3 months after nonsurgical periodontaltherapy.

**Results**

Theclinical parameters showed pronounced reduction at the end of 3 months in allthe groups. CRP reduced in all the three groups 3 months post-operatively, butstatistically significant reduction was seen in Group I and group III only.TSAT increased significantly in all the three groups. With regard to serumferritin, it was seen that serum ferritin increased significantly in Group Iand Group II, whereas significant reduction was seen in Group III.

**Conclusion**

It was noted that nonsurgicalperiodontal therapy can bring about reduction in CRP level and also improvementin iron indices in systemically healthy periodontitis patients and also inchronic kidney disease patients undergoing haemodialysis of varying duration.However studies with larger sample size and longer duration of follow up arerequired to confirm the findings.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02-15
• Study Completion: 2016-10-19
• Last Update Posted: 2022-02-18

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Group I: Renal patients undergoing haemodialysis for less than a year with chronic periodontitis i.
• Patients with Chronic periodontitis will be diagnosed when there is attachment loss ≥5mm in more than 30% of teeth (according to the criteria of 1999 American Academy of Periodontology Workshop).
• Patients with more than or equal to 20 teeth iii.
• Patients with clinical bleeding on probing.
• Patients undergoing haemodialysis for atleast 3months and less than a year.
• Group II: 20 renal patients undergoing haemodialysis for more than a year with chronic periodontitis i.
• Patients undergoing haemodialysis for more than a year.
• Group III: 20 systemically healthy periodontitis patients i.
• Patients with more than or equal to 20 teeth iii.Patients with clinical bleeding on probing.

Exclusion Criteria

• 1.Individuals with uncontrolled hypertension inspite of medication 2.Edentulous patients 3.Smokers, alcoholics, pregnant women and lactating mothers.
• 4.Patients needing prophylactic antibiotic medication in association with periodontal probing.
• 5.Patients who had undergone periodontal treatment in the past 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) C reactive protein level	1 month
2) Iron Indices - Serum Iron, Serum Ferritin, Total Iron binding capacity	1 month

Secondary Outcome Measures

Name	Time	Method
1) Plaque index	2) Gingival Index

Trial Locations

Locations (1)

Sree Mookambika Institute of Dental Sciences; 🇮🇳 Kanniyakumari, TAMIL NADU, India

Sree Mookambika Institute of Dental Sciences

🇮🇳Kanniyakumari, TAMIL NADU, India

Sheethel Menon

Principal investigator

9947020908

drsheethelmenon@gmail.com