Effect of nonsurgical periodontal therapy on C-reactive protein and iron indices in haemodialysis patients with chronic periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1) C reactive protein level
研究概览
简要总结
Chronicperiodontitis, a inflammatory disease of supporting tissues of teeth, is foundto increase the systemic inflammatory burden possibly facilitated by acutephase reactants like C-reactive protein (CRP), which aggravates the existingmetabolic conditions like diabetes, hypertension and anemia in chronic kidneydisease(CKD) patients undergoing haemodialysis
Aim of the study
To evaluate effect of non-surgicalperiodontal therapy on clinical, renal and haematological parameters atbaseline and 3 months postoperatively.
Materials andMethods
Thiswas a comparative interventional study. Sixty chronic periodontitis patientswere divided into three groups which consisted of CKD patients undergoinghaemodialysis for less than a year (Group I), CKD patients undergoing haemodialysisfor more than a year (Group II) and systemically healthy chronic periodontitispatients(Group III). Clinical parameterswere recorded at baseline, 1 month and 3 months after nonsurgical periodontaltherapy. C reactive protein (CRP), transferrin saturation (TSAT) and serumferritin was observed at baseline and 3 months after nonsurgical periodontaltherapy.
Results
Theclinical parameters showed pronounced reduction at the end of 3 months in allthe groups. CRP reduced in all the three groups 3 months post-operatively, butstatistically significant reduction was seen in Group I and group III only.TSAT increased significantly in all the three groups. With regard to serumferritin, it was seen that serum ferritin increased significantly in Group Iand Group II, whereas significant reduction was seen in Group III.
Conclusion
It was noted that nonsurgicalperiodontal therapy can bring about reduction in CRP level and also improvementin iron indices in systemically healthy periodontitis patients and also inchronic kidney disease patients undergoing haemodialysis of varying duration.However studies with larger sample size and longer duration of follow up arerequired to confirm the findings.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Group I: Renal patients undergoing haemodialysis for less than a year with chronic periodontitis i.
- •Patients with Chronic periodontitis will be diagnosed when there is attachment loss ≥5mm in more than 30% of teeth (according to the criteria of 1999 American Academy of Periodontology Workshop).
- •Patients with more than or equal to 20 teeth iii.
- •Patients with clinical bleeding on probing.
- •Patients undergoing haemodialysis for atleast 3months and less than a year.
- •Group II: 20 renal patients undergoing haemodialysis for more than a year with chronic periodontitis i.
- •Patients undergoing haemodialysis for more than a year.
- •Group III: 20 systemically healthy periodontitis patients i.
- •Patients with more than or equal to 20 teeth iii.Patients with clinical bleeding on probing.
排除标准
- •1.Individuals with uncontrolled hypertension inspite of medication 2.Edentulous patients 3.Smokers, alcoholics, pregnant women and lactating mothers.
- •4.Patients needing prophylactic antibiotic medication in association with periodontal probing.
- •5.Patients who had undergone periodontal treatment in the past 6 months.
结局指标
主要结局
1) C reactive protein level
时间窗: 1 month
2) Iron Indices - Serum Iron, Serum Ferritin, Total Iron binding capacity
时间窗: 1 month
次要结局
- 1) Plaque index(2) Gingival Index)