The etiology of generalized osteoporosis in rheumatoid arthitis

Completed

• Conditions: osteoporose; rheumatism; 10003816; 10023213

• Registration Number: NL-OMON38259
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

early RA patients with high disease activity (DAS28 > 5.2)
RA patients in remission (DAS28 < 2.6)
healthy controls
healthy donors for bone cell culture:surplus bone tissue

Exclusion Criteria

excluded will be male or female patients documented with inflammatory disease other then RA, cholestatic disease, use of glucocorticoids or bisphosphonates, pregnancy, breast-feeding, metabolic bone disease (unless stable osteoporosis), hyperthyroidism, and hypothyroidism.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1.. Elucidated the different effects of serum of RA patients on osteoblasts,<br /><br>and osteocytes.<br /><br>2. Obtained a list of pro-inflammatory cytokines in serum of RA patients<br /><br>Identified of these cytokines near bone cells in the bone tissue<br /><br>3. Determined the specific action of the discovered factors on osteoblast,<br /><br>osteocyte and formation and function. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>