Randomized trial of Lipid lowering Therapy for Endothelial Function;Statin Monotherapy Compared with Statin/Ezetimibe or Statin/Eicosapentaenoic Acid Combination Therapy

Phase 4

• Conditions: Ischemic heart disease, Coronary atherosclerosis

• Registration Number: JPRN-UMIN000008060
• Lead Sponsor: Fukuoka wajiro hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-31
• Study Completion: 2019-12-05
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

1.Patients with liver disease (ALT or AST level is over 100IU/L, total Bil level is over 2.5mg/dl). 2.Patients with renal insufficiency (serum creatinine level is over 2.0mg/dl, or creatinine clearance is under 30mL/min/1.73m2). 3.Patients with congenital heart disease. 4.Patients within 3 months from myocardial infarction and with highly advanced cardiac dysfunction. 5.Patients with endocrine disease. 6.Patients with malignancy or inflammatory disease. 7.Patinets with highly advanced respiratory disease (containing pulmonary arterial pulmonary hypertension. 8.Patients with cranial nerve disease or locomotor apparatus disease, and severely compromised daily life. 9.Patients with severe hypertension. 10.Patients administrated steroid or immune suppressor. 11.Patients with type1 DM or poorly controled type2 DM(FBS>200mg/dl, HbA1c>10.0%) 12.Patients during pregnancy or with possibility of pregnancy. 13.Patients administrated catecholamine. 14.Patients with symptomatic hypotension. 15.Patients with significant LVOT obstruction (Hypertrophic obstructive cardiomyopathy or aortic stenosis). 16.Patients recognized inadequate by primary doctor.

Study & Design

• Study Type: Interventional
• Study Design: Not specified