Optimal Protein Intake to Maximize Whole-Body Protein Balance in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Optimal protein intake
研究概览
简要总结
The purpose of this study is to assess the optimal protein intake to maximize whole-body protein net balance in healthy adults. In a randomized, double-blinded, crossover design, 12 young, healthy adult males and females aged 18-35 years, will consume a test diet consisting of free amino acid mixtures based on milk protein that vary in protein content 7 separate acute metabolic trials. The main study endpoint is optimal protein intake based on the lowest protein intake that maximizes whole-body protein net balance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 18-35 years
- •BMI between 18.5-30 kg/m2
- •Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
- •No physical limitations (i.e., able to perform all activities associated with daily living independently)
排除标准
- •Diagnosed musculoskeletal disorders
- •Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
- •Chronic use of gastric acid-suppressing medication or anti-coagulants
- •Unstable weight over the last three months
- •Diagnosed GI tract disorders or diseases
- •Blood donation in the past 2 months
- •Females: pregnancy
研究组 & 干预措施
1.8 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
0.4 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
0.6 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
0.8 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
1.0 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
1.2 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
1.5 g protein･kg BM-1･d-1
干预措施: Amino Acid (Dietary Supplement)
结局指标
主要结局
Optimal protein intake
时间窗: From enrolment through to study completion, minimum 7 weeks
The optimal protein intake to maximize whole-body protein synthesis rates in healthy, young males and females based on the consumption of milk protein.
次要结局
未报告次要终点