Comparative study of C-reactive protein levels and periodontal outcomes in chronic periodontitis patient undergoing Non-Surgical Periodontal Therapy with subgingival irrigation of propolis extract versus chlorhexidine digluconate - A randomized controlled trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in C reactive protein levels measured at baseline and 1 month
研究概览
简要总结
This randomized controlled trial aims to compare the effects of subging`val irigation wit propolis extract and chlorhexidine dia luconate as adf undts to non-suroi cal perfodo tal therapy (NSPT) in chronic periodontitis patients. Sidy participants will be randomly allocated into two groups: Group A (10% propols aatract) and Group B (02% chlorhexi digluconate). C-reactive protein (CRP) levels and periodontal paramcters - probing depth, dinical attachment level, gingival index, and plague index- w I be eralated at baserne 1 month, and 3 months The study expects both interventions to reduce inlammation and improve dinical outcomes, with propols potentie lly oflering comp-rable or supei efficacy to chlorhexidine
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Chronic Periodontitis Probing pocket Depth 3-6mm No history of periodontal treatment in last 6 months No systemic disease affecting periodontal health.
排除标准
- •Systemic disease like diabetes, cardiovascular disease pregnant or lactating females current tobacco chewer or smoker allergy to propolis or chlorhexidine antimicrobial therapy during or before treatment pocket depth greater than 6 mm.
结局指标
主要结局
Change in C reactive protein levels measured at baseline and 1 month
时间窗: 6 months
次要结局
- periodontal parameters measured at baseline 1 month and 3 months(6 months)
研究者
Dr Jha Sonuanand
Government Dental College and Hospital Jamnagar