Seoul National University Prospectively Enrolled Registry for Prostate Cancer With Active Surveillance
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 410
- 试验地点
- 1
- 主要终点
- Pathological reclassification
研究概览
简要总结
In this study, the investigators aim to establish the prostate cancer active surveillance prospective cohort in our institution, and finally investigate the 5 year rates of reclassification during active surveillance as the primary endpoint of the current study.
详细描述
Prostate cancer (PCa) remains one of the most commonly diagnosed malignancies in men worldwide. Early diagnosis and definitive therapy seem to improve oncological outcomes in men with high-risk disease, but significant concerns exist in terms of the overdiagnosis and overtreatment of patients with lower-risk tumors. In this context, active surveillance (AS) has recently emerged as a alternative treatment strategy in PCa patients with low risk cancers. However, published data are based on Western population with different protocol, and therefore; well-controlled data with well-organized and prospective cohort are urgently needed in Korean patients with low-risk PCa because Korean patients have significantly different tumor characteristics compared to Western patients. Here, the investigators have a plan to establish the Seoul National University Enrolled Registry for Prostate Cancer with Active Surveillance, and finally provide the concrete evidence for the clinical outcomes of active surveillance program as the primary therapeutic strategy for low-risk PCa in Korean men.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years(Adult, Older Adult)
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Men < 80 years
- •Pathologically proven adenocarcinoma of the prostate by transrectal prostate biopsy ≥ 10 cores
- •Pre-Bx PSA ≤ 10ng/ml
- •PSA density < 0.15ng/ml/ml
- •Clinical stage T1-2a
- •Biopsy Gleason score ≤ 6
- •No. of positive cores ≤ 2
- •Maximum cancer involvement in any one core ≤ 20%.
- •No PIRADS 5 lesion on multiparametric prostate MRI (1.5T or 3T)
- •Participants must be willing to attend the follow-up visits - T1a-b disease should be confirmed by systematic TRUS-Bx ≥ 10 cores
排除标准
- •A former therapy for prostate cancer.
结局指标
主要结局
Pathological reclassification
时间窗: 5 year
5-year rate of pathological reclassification during active surveillance
次要结局
- rates of active surveillance maintenance(1, 3, 5, 7, 10 years)
- Utility value (measured by EQ-5D-5L)(1, 3, 5, 7, 10 years)
- metastasis-free survival(3, 5, 10 years)
- overall survival(3, 5, 10 years)
- active treatment-free survival(1, 3, 5, 7, 10 years)
- HRQoL scores (measured by EPIC-CP)(1, 3, 5, 7, 10 years)
研究者
Chang Wook Jeong
Professor
Seoul National University Hospital
