Evaluation of the Possible Effect of Inspiratory Muscle Training on Inflammation Markers and Oxidative Stress in Childhood Asthma
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Ege University
- Enrollment
- 105
- Locations
- 1
- Primary Endpoint
- Inflammatory marker
Study Overview
Brief Summary
As inflammation and oxidative stress increase in asthma patients, the severity of symptoms and clinical findings increase. Therefore, this study was planned to evaluate the possible effect of inspiratory muscle training (IMT) on inflammation markers and oxidative stress in childhood asthma.
The study included asthma patient; 35 routine medication, 35 drug therapy and inspiratory muscle training (IMT), and 35 healthy total 105 children aged 8-17 years. Demographic information and hemogram values were recorded. Functional capacity was evaluated with the 6-minute walking test, quality of life PedsQL, respiratory muscle strength oral pressure measuring device, respiratory function test, dyspnea severity with Modified Borg Scale. C-Reactive Protein (CRP), Periostin, Transforming Growth Factor-βeta (TGF-β), Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) were analyzed. IMT was given with a Threshold IMT device for 7 days/6 weeks at 30% of maximal inspiratory pressure, and then a second evaluation was made.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 8 Years to 17 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Have been diagnosed with asthma,
- •Between the ages of 8-17,
- •No asthma attack,
- •Cooperating with the study,
- •Without cerebral palsy, mental retardation or any other major neurological diagnosis,
- •Agreeing to participate in the study,
- •Cases whose medication has not been changed for at least three weeks.
Exclusion Criteria
- •Presence of kyphoscoliosis that may affect respiration,
- •Having advanced postural alignment problem,
- •Having mental problems,
- •Having neuromuscular disease,
- •Making changes in the medications used in the last three weeks,
- •Presence of inflammatory diseases such as juvenile idiopathic arthritis.
Arms & Interventions
Control Group
Health children
Intervention: Control group (Other)
Used routine medicine group
Followed 6 weeks
Intervention: Used routine medicine (Other)
Inspiratory muscle training group
Threshold IMT was given this group. Applied for 7 days 6 weeks.
Intervention: Inspiratory muscle training (Other)
Inspiratory muscle training group
Threshold IMT was given this group. Applied for 7 days 6 weeks.
Intervention: Used routine medicine (Other)
Outcomes
Primary Outcomes
Inflammatory marker
Time Frame: 6 weeks
We assessed C reaktive protein from Blood sample
Oxidative stress
Time Frame: 6 weeks
We assessed Total oxidative level.
Secondary Outcomes
- functional capacity(6 weeks)
- Quality life(6 weeks)
- Pulmonary function test(6 weeks)
- Respiratory muscle strength(6 weeks)
Investigators
Ozden Gokcek
Principal Investigator
Ege University