Cranberry Consumption Improves γδ T Cell Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Florida
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Change in Immune Cell Function
Study Overview
Brief Summary
The purpose of this study is to determine the extent to which consuming a cranberry beverage modifies immune function, specifically related to γδ T cells and other innate immune cells. It is hypothesized that cranberry components will interact with immune cells to activate signaling pathways that enhance cell function. Enhanced immune cell function should result in reduced number, duration, and severity of cold and flu symptoms.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 21 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •between 21 and 35 years of age and in good health
- •have a BMI between 18.5 and 29.9
- •willing to consume the study beverage for 12 weeks
- •willing to have a small amount of blood drawn two times
- •willing to stop consuming tea and immune-enhancing dietary supplements (e.g. antioxidant-, probiotic-, or flavonoid-containing supplements, fish oil, and Echinacea) before and during the 12 weeks of the study
- •willing to consume no more than 7 servings of fruits and vegetables a day
- •willing to limit your alcohol consumption to no more than 14 glasses a week
- •willing to limit your yogurt consumption to no more than one 8oz. serving per day
Exclusion Criteria
- •have food allergies
- •have hypertension
- •taking non-steroidal anti-inflammatory drugs on a chronic basis, antibiotics, or immunosuppressive drugs
- •sensitive to aspirin or prone to kidney stones
- •current smoker
- •pregnant, lactating, or on hormone therapy, except for birth control pills
Arms & Interventions
Cranberry Beverage
Cranberry Beverage is provided in an 8 oz daily beverage consumed once daily for 12 weeks
Intervention: Cranberry Beverage (Other)
Placebo Beverage
The placebo beverage looks like the active arm and is given in the same way but contains no active ingredient.
Intervention: Placebo Beverage (Other)
Outcomes
Primary Outcomes
Change in Immune Cell Function
Time Frame: Measured at baseline and 6 weeks
* Change in leukocyte phenotype * Change in the ability of the natural killer and/or γδ T cells to proliferate when cultured ex vivo * Change in peripheral blood mononuclear cell cytokine and chemokine production in response to mitogens
Secondary Outcomes
- Cold and Flu Symptoms(12 weeks)