Molecular and Cellular Characterization of Skull Base Tumors
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University of Pittsburgh
- Enrollment
- 4,000
- Locations
- 1
- Primary Endpoint
- Patient overall survival will be measured and reported.
Overview
Brief Summary
The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.
Detailed Description
The overall goal of this proposal is to determine new molecular and cellular features that define tumor subtypes that are clinically actionable, may drive important changes in patient management, and/or elucidate novel chemotherapeutic options. Skull base tumors are currently diagnosed based on histopathologic criteria, on which post-operative management is based. However, the investigators hypothesize that each tumor type (eg. chordoma or chondrosarcoma) will have molecular and/or cellular subcategories that will redefine how to categorize and diagnose patients, predict clinical outcome, and optimally design a patient-specific management strategy. In addition, we aim to catalogue changes that occur after treatment after surgical resection, chemotherapy, and/or radiation by comparing primary and recurrent tumors.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosis of a skull base tumor
Exclusion Criteria
- •Insufficient tumor sample at time of resection
Outcomes
Primary Outcomes
Patient overall survival will be measured and reported.
Time Frame: Through study completion, an average of 10 years
There will be one outcome measure: overall survival.
Secondary Outcomes
No secondary outcomes reported
Investigators
Paul Gardner
Associate Professor
University of Pittsburgh