A study to evaluate cost effectiveness and safety of pain killers with and without acid reducing drugs in patients having pain in knee.
- Conditions
- Health Condition 1: null- knee osteoartharitis
- Registration Number
- CTRI/2013/05/003618
- Lead Sponsor
- DrMehwishmajeed
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 94
1.Patientsâ?? aged 45 years or older of either sex.
2.Patients consulting for non-traumatic knee pain/primary symptomatic knee OA.
3.Complying to the clinical American College of Rheumatology (ACR) criteria for osteoarthritis of the knee.
4.A score of 3 or more on the pain severity scale (0-10 scale).
5.Patient willing to provide informed written consent
. Contra-indication for NSAID or Paracetamol use (these are: Gastrointestinal bleedings in history or active peptic ulcer, serious liver or kidney disease (glomerular filtration less than 30 ml/min),
2. An arthroplasty or osteotomy of the knee.
3. Surgery or major trauma of the affected joint within the previous 6 months
4.Pregnancy and lactating women.
5.Patients who were treated with corticosteroid and hyaluronic injection to the target joint within two months prior to the study medication administration.
6. Patient having osteoarthritisfor more than 5 years.
7.Patients with Rheumatoid arthritis, Ankylosing spondylitis, Active gout or active pseudo-gout.
8.Patients advised physiotherapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1 KOOS questionnaire:The Knee injury and Osteoarthritis Outcome Score <br/ ><br>2.Efficacy by VAS(Visual analogue score) questionnaire <br/ ><br>3.Cost effective analysis between Tramadol and diclofenac <br/ ><br>4.adverse effects of Tramadol and DiclofenacTimepoint: 2 and 4 wks
- Secondary Outcome Measures
Name Time Method 1. relation between demographic profile of patients and knee osteoarthritis <br/ ><br>2.The quality of life of osteoarthritis patients by KOOS <br/ ><br>4. To compare cost effectiveness of Diclofenac with H2 blocker or PPI <br/ ><br> <br/ ><br>Timepoint: 2 and 4 wks <br/ ><br>