Effect Of Intravenous Metoprolol Tartrate On Mortality In Patients With Septic Shock Due To Ventilator-Associated Pneumonia
Phase 2
- Conditions
- Circulatory SystemRespiratory
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Adult patients (= 18 years old).
Diagnosed with septic shock secondary to ventilator-associated pneumonia (VAP).
Presenting with sinus tachycardia.
Hemodynamically stabilized with mean arterial pressure (MAP) > 65 mmHg.
Willingness to participate and provide informed consent.
Exclusion Criteria
Contraindications to beta-blockers.
History of heart failure.
Previous use of beta-blockers prior to septic shock.
Development of complications from beta-blocker administration.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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What molecular mechanisms underlie metoprolol tartrate's impact on mortality in septic shock patients with ventilator-associated pneumonia (NCT ID PACTR202404531355476)?
How does intravenous metoprolol tartrate compare to standard vasopressor therapy in reducing mortality for septic shock due to ventilator-associated pneumonia (NCT ID PACTR202404531355476)?
Which biomarkers (e.g., lactate, SOFA score, cytokine profiles) predict response to metoprolol tartrate in septic shock caused by ventilator-associated pneumonia (NCT ID PACTR202404531355476)?
What adverse events (e.g., hypotension, bradycardia) are associated with metoprolol tartrate in septic shock and how are they managed (NCT ID PACTR202404531355476)?
Are there combination therapies or alternative beta-blockers (e.g., esmolol, propranolol) that enhance outcomes in septic shock compared to metoprolol tartrate (NCT ID PACTR202404531355476)?