EFFECTS OF TREATMENT OF SEMEN ABNORMALITIES WITH CLOMIPHENE CITRATE
- Conditions
- Health Condition 1: null- NORMOGONADOTROPHIC OLIGOZOOSPERMIA
- Registration Number
- CTRI/2012/05/002689
- Lead Sponsor
- DR SUDHINDRA MOHAN BHATTACHARYA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
HUSBANDS OF INFERTILE COUPLES WILL UNDERGO SEMEN ANALYSIS. THOSE WITH OLIGOZOOSPERMIA (SPERM COUNT LESS THAN 20 MILLION/ML)WILL UNDERGO SERUM FSH AND TESTOSTERONE TESTED. IF FSH VALUE IS NORMAL, THEN CLOMIPHENE CITRATE 25 MG WILL BE GIVEN DAILY ORALLY. AFTER 2 WEEKS FSH AND TESTOSTERONE LEVELS WILL BE MEASURED. IF RESPONSE IS OPTIMUM, THEN IT WILL BE CONTINUED FOR AT LEAST 3 MONTHS FOR FINAL SEMEN ANALYSIS. IF RESPONSE IS SUBOPTIMUM, DOSE OF CLOMIPHENE CITRATE WILL BE INCREASED TO 50 MG DAILY.
THOSE WITH PRIMARY SPERMATOGONIC FAILURE; THOSE WITH HERNIA, HYDROCOELE, KNOWN VARICOCOELE, PAST HISTORY OF EPIDIDYMO-ORCHITIS; THOSE SHOWING INADEQUATE RESPONSE TO 2 WEEKS OF CLOMIPHENE CITRATE 50 DAILY TAKEN FOR AT LEAST 2 WEEKS.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CHANGES IN DIFFERENT SEMEN PARAMETERS- NAMELY, VOLUME,CONCENTRATION, MOTILITY, RAPID PROGRESSIVE MOTILITY, HOS TEST (HYPO-OSMOTIC SWELLING TEST),MORPHOLOGY, DNA- INTEGRITY TEST (BY ACRIDINE ORANGE STAINING TEST)Timepoint: CHANGES IN DIFFERENT SEMEN PARAMETERS AFTER 3 MONTHS OF TREATMENT
- Secondary Outcome Measures
Name Time Method ANY COUPLE SPONTANEOUSLY CONCEIVING WHILE THE HUSBAND IS ON TREATMENT WITHIN THE STIPULATED 3 MONTHS TIME PERIOD.Timepoint: 3 MONTHS.