Renal Effects of Levosimendan in Cardiac Surgery Patients
Completed
- Conditions
- Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery
- Registration Number
- NCT01918618
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
- Patients undergoing cardiac surgery (OPS 5-35 bis 5-37) between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital
Exclusion Criteria
- Patients younger 18
- Preexisting renal insufficiency
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of plasma creatinine (Difference in renal function) last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4 Only in patients not requiring renal replacement therapy
Change of urine output after surgery (difference in renal function) post-op day 1, 2, 3, 4 Only in patients not requiring renal replacement therapy
Cumulative incidence and duration of hemodialysis (Difference in renal function) last day of hospital stay
- Secondary Outcome Measures
Name Time Method Cumulative Length of stay (hospital and ICU) last day of hospital stay In-hospital mortality last day of hospital stay
Trial Locations
- Locations (1)
Charité - University Medicine Berlin
🇩🇪Berlin, Germany