Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning in Impaired Glucose Tolerant (IGT) Men

Not Applicable

Completed

• Conditions: Glucose Intolerance
• Interventions: Dietary Supplement: low feeding frequency (3x); Dietary Supplement: High feeding frequency (14x)

• Registration Number: NCT01456754
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (IGT) men.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-12
• Primary Completion: 2011-09
• Study First Submitted: 2011-09-26
• Study First Submitted QC: 2011-10-19
• Study First Posted: 2011-10-21
• Study Completion: 2011-11
• Status Verified: 2011-12
• Last Update Submitted: 2011-12-14
• Last Update Posted: 2011-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• BMI: 20-35 kg/m2
• Gender: Male
• Age: subjects has to be older than 18 and younger than 70 years old
• Impaired Glucose Tolerant (IGT) = plasma glucose, two hours after consuming 75g glucose, appears to be superior to 7.8mmol/l (normal level) but remains inferior to 11.1mmol/l (diabetes level) and fasting plasma glucose is less than 7.0mmol/l.
• Caucasian

Exclusion Criteria

1. Lactose intolerant
2. Diabetes Mellitus
3. Cardiovascular diseases
4. Stomach and intestinal diseases
5. Normal glucose levels after 2 hours
6. Anticoagulants
7. Medication that has a effect on energy and glucose homeostasis and absorption of foods
8. Conditions or situations when subjects can't lose 500 ml blood

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
low feeding frequency (3x)	low feeding frequency (3x)	-
High feeding frequency (14x)	High feeding frequency (14x)	-

Primary Outcome Measures

Name	Time	Method
Insulin metabolism	24 hour profile
Glucose metabolism	24 hour profile

Secondary Outcome Measures

Name	Time	Method
Metabolic markers (FFA and TG metabolism)	24 hour profile
Change in substrate partitioning (fat, carbohydrate and protein oxidation) between the two intervention diets	24 hour profiles

Trial Locations

Locations (1)

University of Maastricht; 🇳🇱 Maastricht, Netherlands