Heart Rate Variability in pre-clinical and clinical arthritis - HRV arthritis

Academisch Medisch Centrum0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•All subjects: 18-85 years
•Individuals with pre-clinical arthritis (n<=60): Arthralgia and elevated ACPA level of > 25 IU/ml, or IgM-RF of > 49 IU/ml.
•RA patients with active disease (n<=20): Has been diagnosed according to ACR criteria (Appendix 4: ACR -criteria) and have active arthritis in one or more joints at time of HRV-measurement
•Healthy subjects (n<=20): Negative for IgM-RF (level < 49 IU/ml) and ACPA (level of < 25 IU/ml)

•All subjects
•* Cardiovascular disease; such as ischaemic heart disease, cardiomyopathy, cardiac arrhythmia, cerebrovascular events, hypertension
•* Neurological disorders, such as parkinsonism and multiple sclerosis
•* Diabetes Mellitus and Hypercholesterolemia
•* Medication influencing blood pressure or heart rate
•* Pregnancy
•* Nicotine use (smoking , nicotinegum or patch)
•Individuals with Pre-clinical Arthritis
•* Clinically evident arthritis
•* Use of Disease Modifying Anti-Rheumatic Drugs (DMARDs)
•* Systemic or intra-articular corticosteroid injection less then 28 days before enrolment
•Active RA patients
•* Use of TNF-blockers or anti-IL6 treatment

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