Dietary Inorganic Nitrate: Effects on Metabolic Rate, Reactive Oxygen Species Production, Glucose Uptake and Primary Myotube Respiration.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Resting metabolic rate
研究概览
简要总结
The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Chronic medication Vegetarian Nicotine Users Known metabolic disease
研究组 & 干预措施
Sodium nitrate
0.1 mmol NaNO3 / kg bodyweight / day for three days.
干预措施: Resting metabolic rate (Other)
Sodium nitrate
0.1 mmol NaNO3 / kg bodyweight / day for three days.
干预措施: Glucose Uptake (Other)
Sodium Chloride
0.1 mmol NaCl / kg bodyweight / day for three days.
干预措施: Glucose Uptake (Other)
Sodium Chloride
0.1 mmol NaCl / kg bodyweight / day for three days.
干预措施: Resting metabolic rate (Other)
Sodium nitrite infusion
Sodium nitrite (NaNO2) at a rate of 1, 10 and 100 nmol kg-1 min-1 (10 minutes per dose) was infused intravenously.
干预措施: Nitrite infusion (Other)
Saline infusion
Saline at a rate corresponding to 1, 10 and 100 nmol NaCl kg-1 min-1 (10 minutes per dose) was infused intravenously.
干预措施: Nitrite infusion (Other)
结局指标
主要结局
Resting metabolic rate
时间窗: day 4
Resting metabolic rate, measured after overnight fast using indirect calorimetry
次要结局
- Thyroid hormone status(day 4)
- Nitrite infusion(30 minutes)
- Glucose uptake(day 4)
研究者
Eddie Weitzberg
Professor
Karolinska Institutet