Various Serving Sizes of Lentils on Blood Glucose and Insulin

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: 1/4 cup- Small red lentil; Other: 1/2 cup- small red lentil; Other: 1/4 cup- Small green lentil; Other: 1/2 cup- small green lentil; Other: 1/2 cup- corn; Other: 1/4 cup- corn; Other: 1/2 cup- macaroni; Other: 1/4 cup- macaroni; Other: 1/2 cup- white potato; Other: 1/4 cup- white potato; Other: 1/2 cup- white rice; Other: 1/4 cup- white rice

• Registration Number: NCT02940158
• Lead Sponsor: University of Guelph

Brief Summary

The purpose of this study is to assess the effects of consuming either 1/2 or 1/4 cup servings of lentils on post-prandial blood glucose and insulin as compared to 4 types of starchy foods (corn, macaroni, white potato, white rice).

Detailed Description

Eligible participants will undergo a total of 6 study visits. During each visit, a fasted blood sample will be taken by fingerprick, and approximately 500 µL of blood will be dripped into a collection tube. The participant will then consume a meal of either: two types of lentils, corn, macaroni, white rice, or white potato. All study days will be randomized. Each meal will be served in either 1/4 or 1/2 cup servings depending on the study block. Six more blood samples will be taken by fingerprick at 15, 30, 45, 60, 90 and 120 minutes after the beginning of the meal.

Study Timeline

• Study First Submitted: 2016-09-25
• Study Start: 2016-10
• Study First Submitted QC: 2016-10-18
• Study First Posted: 2016-10-20
• Primary Completion: 2018-01-08
• Study Completion: 2018-01-08
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-02
• Last Update Posted: 2018-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

Not provided

Exclusion Criteria

• Tobacco use
• Pregnant or breastfeeding
• Fasting blood glucose ≥ 7.0 mmol/L
• Two hour blood glucose ≥ 11.1 mmol/L after consuming 75g glucose drink (Oral Glucose Tolerance Test beverage)
• Any major medical condition including a history of AIDS or hepatitis
• Medical or surgical event requiring hospitalization within 3 months of randomization
• Any medications except a stable dose (3 months) of oral contraceptives, blood pressure or statin medications
• Blood pressure >140/90 mm Hg
• Natural health products (NHPs) used for glycemic control
• Probiotic supplements
• Dietary fibre supplements
• Consumption of >4 servings of pulses per week
• Food allergy or non-food life threatening allergy
• Shift workers
• Alcohol consumption >14 drinks/week or >4 drinks/sitting
• Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
• Elite athletes

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
1/2 cup	1/2 cup- white rice	1/2 cup serving size arm
1/4 cup	1/4 cup- Small red lentil	1/4 cup serving size arm
1/4 cup	1/4 cup- Small green lentil	1/4 cup serving size arm
1/2 cup	1/2 cup- small green lentil	1/2 cup serving size arm
1/2 cup	1/2 cup- corn	1/2 cup serving size arm
1/2 cup	1/2 cup- macaroni	1/2 cup serving size arm
1/2 cup	1/2 cup- white potato	1/2 cup serving size arm
1/4 cup	1/4 cup- corn	1/4 cup serving size arm
1/4 cup	1/4 cup- white potato	1/4 cup serving size arm
1/4 cup	1/4 cup- macaroni	1/4 cup serving size arm
1/4 cup	1/4 cup- white rice	1/4 cup serving size arm
1/2 cup	1/2 cup- small red lentil	1/2 cup serving size arm

Primary Outcome Measures

Name	Time	Method
Postprandial Blood Glucose	2 hours Postprandial
Postprandial Blood Insulin	2 hours postprandial

Trial Locations

Locations (1)

Human Nutraceutical Research Unit; 🇨🇦 Guelph, Ontario, Canada