Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Change of renal functions
研究概览
简要总结
The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).
详细描述
The investigators will collect the blood samples from patients with suspect ACS. LTBP4 will be the first matrix protein that are going to understand. Upon hospital arrival, blood samples around 8 ml will be collected and the 2nd collection will be two weeks to one month after the event. The third collection will be one year later. In the between, if any ACS event develop, blood samples will be collected as protocols.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •acute coronary syndrome patients
排除标准
- •cardiogenic shock, pregnancy, end-stage renal disease
结局指标
主要结局
Change of renal functions
时间窗: One month, Six month and one year
The investigators will follow up Cr and eGFR levels correlate with LTBP4 levels
Incidence of required myocardial revascularization
时间窗: 3 years
All cause mortality
时间窗: 3 years
Incidence of hospitalization
时间窗: 3 years
次要结局
未报告次要终点