Methicillin-resistant Staphylococcus aureus: Occupational exposure, dynamics of carriage and associated disease in livestock farmers and their household members.

Completed

Conditions: hospital bacteria
MRSA
10004018

Registration Number: NL-OMON33440

Lead Sponsor: Sint Elisabeth Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

Individuals of any age are eligible and should be:
1 - Working with pigs or veal calves on a farm (primary exposed)
or
2 - Living on a pig or veal farm and not working with the animals (secondary exposed)

Exclusion Criteria

- Treatment for colonization of MRSA in the last 3 months of any potential participant (farm will be excluded)
- Being colonized with other types of MRSA than CC398

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the prevalence of persistent MRSA carriage in primary<br /><br>versus secondary exposed persons. A secondary case is defined as a household<br /><br>member that carries MRSA-CC398 on a farm were MRSA was found during the study<br /><br>period. Persistent carriage is defined as all samplings being positive for<br /><br>MRSA, intermittent carriage is defined as 1 to 5 out of 6 samples positive. If<br /><br>none of the samples return MRSA it is referred to as non-carriage. Adjustment<br /><br>for factors that may influence persistent carriage, e.g. carriage of<br /><br>methicillin susceptible S. aureus (MSSA), throat carriage, the amount of MRSA<br /><br>present in the nose or throat and the presence of MRSA in wounds or skin<br /><br>diseases will be done. Furthermore, the association between the number of<br /><br>positive samples during the initial 3 swabs and the carriage status at 4, 8 and<br /><br>12 months is determined. This is done for both MSSA and MRSA.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To determine the amount of disease associated with carriage of MRSA-CC398 the<br /><br>occurrence of medical events will be recorded. Not only infections caused by<br /><br>MRSA are included in this follow-up but also visits to the general<br /><br>practitionar, use of antibiotics, hospital admissions etc. Adjustment for<br /><br>factors that may affect the occurrence of disease will be done using regression<br /><br>analysis. Lastly the exposure to dust on MRSA positive farms will be studied,<br /><br>using information from questionnaires, personal dust samplers and environmental<br /><br>samples from house and stable.</p><br>