Correlation Between Oxidative Stress Status and COVID-19 Severity

Completed

• Conditions: Oxidative Stress
• Interventions: Diagnostic Test: Oxidative Stress ELISA Kit

• Registration Number: NCT04375137
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Detailed Description

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Study Timeline

• Study Start: 2020-04-20
• Study First Submitted: 2020-05-03
• Study First Submitted QC: 2020-05-03
• Study First Posted: 2020-05-05
• Primary Completion: 2022-04-01
• Study Completion: 2022-05-30
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-15
• Last Update Posted: 2023-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• more than 18 years old
• positive RT-PCR COVID-19
• compatible lung CT with COVID-19

Exclusion Criteria

• not signing informed consent
• using antioxidants
• using statins

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Severe COVID	Oxidative Stress ELISA Kit	patients with positive PCR or compatible CT admitted in ICU or intubated
Non-severe COVID-19	Oxidative Stress ELISA Kit	patients with positive PCR or compatible CT admitted in ward without hypoxia
Healthy Controls	Oxidative Stress ELISA Kit	Healthy controls with negative IgM/IgG for COVID-19

Primary Outcome Measures

Name	Time	Method
MDA concentration	2 weeks	MDA x 2 ULN in severe COVID

Secondary Outcome Measures

Name	Time	Method
Neopterin rate of increase	2 weeks	Difference between severe and controls
Biopterin concentration	2 weeks	Difference between severe and controls

Trial Locations

Locations (1)

Nooshin Dalili; 🇮🇷 Tehran, Iran, Islamic Republic of