Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Bnai Zion Medical Center
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Blood cortisol
Study Overview
Brief Summary
Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.
Detailed Description
In earlier studies investigators claimed that subnormal cortisol response using plastic tubes might result from cosyntropin adherence to the tube and loss of the delivered dosage. It was shown that 21.6-58.6% of ACTH dosage had not been recovered when pushed through 20.3 cm plastic tube, and loss of ACTH may be up to 70% when cosyntropin was delivered through a plastic 30 cm scalp vein set.
Moreover, it was previously shown that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test. However, in that study, investigators used a 20.3 cm plastic tube, which might have led to uncompleted cosyntropin delivery. In ther current study investigators will study afternoon 1μg cosyntropin cortisol stimulation using a short 2.5 cm tube.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy volunteers
Exclusion Criteria
- •Clinical suspicion of hypoadrenalism Medical condition or treatment that might alter blood cortisol levels Pregnancy
Arms & Interventions
healthy subjects
20 healthy subjects will undergo low dose cosyntropin stimulation test. Serum and salivary cortisol will be measured just before cosyntropin administration and 30 minutes later.
Intervention: low-dose cosyntropin stimulation test (Diagnostic Test)
Outcomes
Primary Outcomes
Blood cortisol
Time Frame: one day
Serum cortisol concentrations during intravenous low dose cosyntropin stimulation through short tube.
Secondary Outcomes
- Salivary free cortisol(one day)
Investigators
leonard.saiegh
MD
Bnai Zion Medical Center