Identification of novel childhood osteosarcoma predisposing genes.

Completed

• Conditions: bone cancer; osteosarcoma; 10040778

• Registration Number: NL-OMON43835
• Lead Sponsor: Genetica

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

20 individulas who have developed osteosarcoma in childhood (<19 years of age) without a syndrome diagnosis after consultation by a clinical geneticist, and their parents.

Exclusion Criteria

- A proven osteosarcoma predisposing condition
- A genetic defect in the family for a cancer unrelated condition, of which the child might be a carrier but about which the child/parents do not want to be informed.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Understanding the molecular etiology and pathogenesis of CRC in AYAs is<br /><br>expected to yield novel genetic risk factors. that will facilitate clinical<br /><br>decision making, including early tumor detection, in AYAs with CRC and their<br /><br>siblings at risk. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Identification of novel genetic risk factors voor CRC will facilitate clinical<br /><br>decision making, including early tumor detection in AYAs with CRC and their<br /><br>siblings at risk.</p><br>