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Investigation of the role of the cannabinoid system in mediating alcohol cue-induced Nucleus accumbens response in individuals with alcohol Use disorder using functional magnetic resonance imaging - ICONIC

Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin0 个研究点目标入组 28 人开始时间: 2022年8月10日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Age between 18 and 60 years
•- Participants meeting the diagnosis of an alcohol use disorder according to the DSM-V
•- Ability of the individual to understand the character and the individual consequences of the study
•- Written informed consent (must be available before enrollment in the study)
•- Consent to random assignment

•- Subjects presenting with any of the following criteria will not be included in the study: Current psychotic or bipolar disorder or current severe depressive episode with suicidal ideations
•- Contraindication for functional magnetic resonance imaging (e.g. metal implants)
•- Any withdrawal symptoms at the time of the study visit (CIWA score >3)
•- Breath alcohol concentration > 0.0 at the time of the study visit
•- Positive drug screening (amphetamines/ecstasy, opiates, cocaine, barbiturates, cannabis, benzodiazepines)
•- Pregnancy, lactation or breastfeeding
•- Current severe somatic comorbidities: liver cirrhosis or severely impaired renal function, severe heart insufficiency, pre-existing epilepsy
•- History of hypersensitivity to Cannabidiol (Arvisol®) or to any drug with similar chemical structure or to any excipient present in the pharmaceutical form of Arvisol®
•- Acute suicidal tendency or acute endangerment of self and others

发起方

Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin