Graduated compression stockings for patients with a deep vein thrombosis to prevent long-term symptoms, known as post-thrombotic syndrome

Not Applicable

• Conditions: Post-thrombotic syndrome; Circulatory System; Postthrombotic syndrome

• Registration Number: ISRCTN73041168
• Lead Sponsor: Imperial College of Science, Technology and Medicine

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33846151/ (added 14/04/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-10-30
• Last Update Posted: 10 October 2022
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: Stopped
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

1. Symptomatic presentation of first deep vein thrombosis, < 2 weeks from diagnosis
2. Imaging confirmed, lower limb deep vein thrombosis (popliteal, femoral, iliac or combination)
3. Ability to give informed consent
4. Age 18 or over

Exclusion Criteria

Current participant exclusion criteria as of 21/12/2021:
1. Life expectancy < 2 years
2. Contraindication to wearing graduated compression stockings
3. Previously intolerant of or already wearing graduated compression stockings for more than 1 month
4. Ankle brachial pressure index (ABPI) < 0.8 or pedal pulses absent
5. Bilateral deep vein thrombosis
6. Previous chronic venous insufficiency (patients with existing chronic skin changes or ulceration, defined as C5 or C6 by CEAP classification)
7. Pre-existing post thrombotic syndrome, significant leg pain (e.g. knee arthritis, spinal claudication) or oedema (e.g. lymphoedema)
8. Newly diagnosed cancer, metastatic cancer, or cancer undergoing active treatment or palliation
9. Contraindication to anticoagulation
10. Known allergy to fabric in compression stockings

Previous participant exclusion criteria:
1. Life expectancy < 2 years
2. Contraindication to wearing graduated compression stockings
3. Previously intolerant of or already wearing graduated compression stockings for more than 1 month
4. Ankle brachial pressure index (ABPI) < 0.8 or pedal pulses absent
5. Bilateral deep vein thrombosis
6. Previous chronic venous insufficiency (patients with existing chronic skin changes or ulceration, defined as C4,5,6 by CEAP classification)
7. Pre-existing post thrombotic syndrome, significant leg pain (e.g. knee arthritis, spinal claudication) or oedema (e.g. lymphoedema)
8. Newly diagnosed cancer, metastatic cancer, or cancer undergoing active treatment or palliation
9. Contraindication to anticoagulation
10. Known allergy to fabric in compression stockings

Study & Design

• Study Type: Interventional
• Study Design: Not specified