Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Not yet recruiting

• Conditions: Phenocopy Frontotemporal Dementia (phFTD); Bipolar Disorder; Behavioral Variant of Frontotemporal Disorder (bvFTD); Frontal Variant of Alzheimer Disease
• Interventions: Other: Submission of the NEO-PI-3 questionnaire; Other: Submission of the Interpersonal Reactivity Index questionnaire (IRI)

• Registration Number: NCT06059313
• Lead Sponsor: Nantes University Hospital

Brief Summary

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility.

The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-09
• Study First Submitted: 2023-09-22
• Study First Submitted QC: 2023-09-22
• Study First Posted: 2023-09-28
• Last Update Submitted: 2023-09-29
• Study Start: 2023-10-01
• Last Update Posted: 2023-10-03
• Primary Completion: 2026-10-01
• Study Completion: 2027-02-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Behavioral variant of frontotemporal disorder (bvFTD)	Submission of the Interpersonal Reactivity Index questionnaire (IRI)	A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia
Phenocopy frontotemporal dementia (phFTD)	Submission of the NEO-PI-3 questionnaire	A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.
Frontal variant of Alzheimer disease	Submission of the Interpersonal Reactivity Index questionnaire (IRI)	A group of participants who fulfill Ossenkopele criteria (2022)
Phenocopy frontotemporal dementia (phFTD)	Submission of the Interpersonal Reactivity Index questionnaire (IRI)	A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.
Bipolar disorder	Submission of the NEO-PI-3 questionnaire	A group of participants who fulfill CIM 10 criteria
Behavioral variant of frontotemporal disorder (bvFTD)	Submission of the NEO-PI-3 questionnaire	A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia
Bipolar disorder	Submission of the Interpersonal Reactivity Index questionnaire (IRI)	A group of participants who fulfill CIM 10 criteria
Frontal variant of Alzheimer disease	Submission of the NEO-PI-3 questionnaire	A group of participants who fulfill Ossenkopele criteria (2022)

Primary Outcome Measures

Name	Time	Method
Premorbid personality traits	Baseline	Premorbid personality traits will be assessed by the NEO- NEO Personality Inventory-3 (NEO-PI-3). The NEO PI-3 measures the five major domains of personality: Neuroticism, Extraversion, Openness to experience, Conscientiousness and Agreeableness. Each domain is defined by 6 facets. NEOPI-3 includes 240 items and responses are made on a 5-point Likert -type scale ranging from strongly Disagree to strongly agree. The NEOPI 3 will be completed by a caregiver who has known the patient in the 10 years preceding the disease onset.

Secondary Outcome Measures

Name	Time	Method
Interpersonal Reactivity Index (IRI)	Baseline	IRI is a 28-item questionnaire measuring 4 aspects of empathy : perspective-taking, fantasy, empathic concern, personal distress. Each answer is rated from 1 (does not describe me well) to 5 (describes me very well).