Relation of 3rd Trimester Uterine Artery Doppler Flow Velocimetry Indices, Factor V Leiden Mutation and Placental Pathology to the Severity of Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator
研究概览
简要总结
this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes
详细描述
leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •severe preeclampsia in 3rd trimester -
排除标准
- •Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy.
结局指标
主要结局
percentage of fetuses and neonates complicated with intrauterine fetal death or need admission to incubator
时间窗: from diagnosis of severe preeclampsia till one week after delivery
IUFD, admission to neonatal IUC
percentage of patients develop abruption placenta, intrauterine growth retardation or delivered premature
时间窗: within 12 wks from diagnosis of severe preeclampsia
placental abruption, prematurity, IUGR
次要结局
未报告次要终点
研究者
Olfat Nooh Riad Ali
professor
Cairo University