To Study the Effect of β-glucans on Wound Healing

Not Applicable

Completed

• Conditions: Burns
• Interventions: Drug: oral sugar powder; Dietary Supplement: oral beta-glucans

• Registration Number: NCT02078128
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this study is to determine the effect of β-glucans on wound healing.

Detailed Description

The structure of βeta-glucan (β-glucans) is a pathogen associated molecular patterns (pathogen-associated molecular patterns, PAMPs), widely present in the cell walls of plants, bacteria, yeasts, fungi, mushrooms and algae. Modern has been reported in the literature that β-glucan can enhance the immune system of animals, and to enhance the function of the animal against bacterial, fungal and viral infections, and cancer.In this study, the use of β-glucan to enhance the biological characteristics of the non-specific immunity, to explore the impact of postoperative patients with wound healing and infection rates.The observation of the healing process to take the Leather District wounds (5 \~ 200 cm2). The experiments were carried out for 18 months, were observed record the following three: (1) the rate of wound healing, (2) The rate of infection assessment: record length of time and the point in time at all levels of antibiotic use also observe the wound change (redness, swelling, heat, pain).(3) days of hospitalization, and spend statistics. Using unpaired student's t-test analysis, group data whether the differences between groups of experimental data. represents a statistically significant when p \<0.05.

Study Timeline

• Study Start: 2011-07
• Primary Completion: 2011-08
• Study First Submitted: 2012-09-17
• Study Completion: 2013-02
• Status Verified: 2014-03
• Study First Submitted QC: 2014-03-03
• Last Update Submitted: 2014-03-03
• Study First Posted: 2014-03-05
• Last Update Posted: 2014-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Total burn area under 20%, two to three degree burn and need skin-grafting.
2. Subjects don't have other diseases.
3. Subjects' age between 20 to 60.

Exclusion Criteria

1. Subjects with hypersensitivity.
2. Subjects with Autoimmune disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oral beta-glucans	oral sugar powder	Daily give kg per day to 30 mg of β-glucan (30mg/kg/day), taking to the wound healed.
oral sugar powder	oral beta-glucans	control group, daily give and the glucose powder 30 mg per kilogram of body weight (30mg/kg/day) a day, taking to the wound healed.

Primary Outcome Measures

Name	Time	Method
Wound healing percentage	every Monday and Thuresday for the duration of hospital stay, an expected average of 3 weeks	record data by taking picture

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan