CTRI/2022/04/041981招募中未知
Efficacy and Safety of Pentoxifylline in Improving Oxygenation in Hepatopulmonary Syndrome: A Randomized Double-blind Placebo-controlled Trial
试验速览
- 阶段
- 未知
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Age 18 ââ?¬â?? 70 years
- •2.Evidence of portal hypertension
- •3.Intrapulmonary vascular dilatation in the form of shunting diagnosed on contrast echocardiogram
- •4.AaPO2 > 15mmHg on seated room air (ABG) if age <65years and >20mmHg if Ageââ?°Â¥ 70 years
排除标准
- •1.Child C cirrhosis with CTP > 10 or with refractory ascites
- •2.Intrinsic significant cardiopulmonary disease
- •i.PFT showing severe obstructive ventilatory defect (FEV1/FVC < 70)
- •ii.Hepatic hydrothorax, Portopulmonary hypertension
- •iii.Moderate and severe left ventricular systolic dysfunction
- •iv.Inability to perform Pulmonary function test
- •v.Intracardiac shunting
- •3.Current use of exogenous nitrates
- •4.Patients already on pentoxifylline
- •5.Prior intolerance to pentoxifylline
- •6.Very severe cases of HPS (A-aO2 gradient ââ?°Â¥ 15mm Hg, PO2 <50 mmHg)
- •7.Active bacterial infections, active hepatic encephalopathy
- •8.Known malignancy including HCC
- •9.SBP on secondary prophylaxis
- •10.CKD with creatinine clearance < 30
- •11.Enrolled in other trials
- •12.Has a liver transplant option
研究者
相似试验
招募中
3 期
Evaluating the effectiveness of pentoxifylline on the prevention of gentamicin nephrotoxicityIRCT20161010030246N5Shiraz University of Medical Sciences60
撤回
2 期
Pentoxifylline as a secondary prophylaxis for necrotising enterocolitis in preterm neonatesACTRN12606000257561KEM Hospital for Women, Perth80
招募中
2 期
The effect of pentoxifylline in the treatment of Covid-19 diseaseIRCT20110425006280N11Vice President of Research Guilan university of medical sciences20
已完成
3 期
Efficacy of pentoxifylline in CO2 laser treatment of burn scarsIRCT20230613058476N1Iran University of Medical Sciences22
已完成
不适用
Pentoxifylline and Contrast Induced NephropathyContrast Induced Nephropathy.Acute renal failure (includes acute renal impairment)IRCT201011135161N1Vice-chancellor for Research Affairs, Shiraz University of Medical Sciences199