Is Isokinetic Testing an Indicator of Total Knee Arthroplasty

Not Applicable

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Device: isokinetic testing CSMI HUMAC NORM instrument

• Registration Number: NCT05668546
• Lead Sponsor: Bahçeşehir University

Brief Summary

In this study, investigators analyzed whether the isokinetic knee muscle strength of patients undergoing unilateral total knee arthroplasty (TKA) is a predictor for surgery.

Patients and Methods: In total, 29 unilateral TKA candidates (58 knees; mean age = 66.69 ± 7.42 years; mean symptom duration = 10 ± 5.40 years) were enrolled. The knees of patients with bilateral advanced knee osteoarthritis (stage 3 or 4), according to the Kellgren-Lawrence (K-L scale), that were scheduled for unilateral TKA were divided into surgical and non-surgical groups. An isokinetic testing system was used to assess knee flexor and extensor muscle strength (peak torque) at angular velocities of 60°/s and 180°/s (five cycles per velocity). The radiological (X-ray-based K-L scale and magnetic resonance imaging (MRI)-based quadriceps angle) and clinical findings (isokinetic test and visual analog scale pain scores) in both groups were compared. The isokinetic test results correlated with the radiological findings of the surgery group.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-01
• Primary Completion: 2021-12-01
• Study Completion: 2022-02-01
• Status Verified: 2022-12
• Study First Submitted: 2022-12-08
• Study First Submitted QC: 2022-12-19
• Last Update Submitted: 2022-12-19
• Study First Posted: 2022-12-30
• Last Update Posted: 2022-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Diagnosis of advanced (Kellgren-Lawrence stage 3 or 4) bilateral knee osteoarthritis (OA).
• Unilateral total knee replacement surgery recommended by orthopedics according to pain status

Exclusion Criteria

• Neurological diseases that could affect knee muscle strength
• Rheumatological diseases
• Diagnosis of osteoarthritis below 3 according to Kellgren-Lawrence classification

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
non surgical knee group	isokinetic testing CSMI HUMAC NORM instrument	This study analyzed 58 knees of 29 unilateral TKA candidates, divided into the surgical and non-surgical knee groups
surgical knee group	isokinetic testing CSMI HUMAC NORM instrument	This study analyzed 58 knees of 29 unilateral TKA candidates, divided into the surgical and non-surgical knee groups

Primary Outcome Measures

Name	Time	Method
Osteoartritis gradings assessed by Kellgren-Lawrence grading system	cross sectional study, baseline	Kellgren-Lawrence grading system was used. Each radiograph was assigned a grade from 0 to 4, which correlated to increasing severity of OA, with Grade 0 signifying no presence of OA and Grade 4 signifying severe OA
Quadriceps angle	cross sectional study, baseline	Q angle of knees were recorded. It is defined as the angle formed between the quadriceps muscles and the patella tendon.The Q angle measured in standing. Normal Q angle score for females is between 13-18° and in males is between 12-15°, with values greater than and lesser these are considered abnormal
Knee flexion and extension muscle strengths assessed by isokinetic dynamometer	cross-sectional study, baseline	In the isokinetic evaluation, both 60 PT_E (Peak Torque _Extension) and 60 PT_F (Peak Torque_Flexion) were evaluated.The tests were repeated five times at each velocity, and the highest PTs were selected for statistical analysis. The participants performed repeated trials before sets, while a 20-second rest was provided between sets.
Pain assessed by Visual analog scale	cross sectional study, baseline	The visual analog scale (VAS) pain score of each individual was also recordedThe Visual Analogue Scale (VAS) measures pain intensity. The VAS consists of a 10cm line, with two end points representing 0 ('no pain') and 10 ('pain as bad as it could possibly be'). Investigators asked the patient to rate their current level of pain by placing a mark on the line.

Trial Locations

Locations (1)

Memorial Sisli Hospital; 🇹🇷 Istanbul, Turkey