A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes
- Conditions
- Diabetes Mellitus, Type 2
- Interventions
- Drug: Placebo (semaglutide)
- Registration Number
- NCT03914326
- Lead Sponsor
- Novo Nordisk A/S
- Brief Summary
The researchers are doing this study to look whether the type 2 diabetes medicine, semaglutide, has a positive effect on heart disease. Participants will either get semaglutide tablets or placebo tablets ("dummy" medicine) - which treatment is decided by chance. Participants must take one tablet with water every morning on an empty stomach and not eat or drink anything for at least 30 minutes. The study will last for about 3.5-5 years. Participants will have up to 25 clinic visits and 1 phone call with the study doctor. Women cannot be in the study if pregnant, breast-feeding or if they plan to become pregnant during the study period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 9642
-
Male or female, age equal to or above 50 years at the time of signing informed consent
-
Diagnosed with type 2 diabetes mellitus
-
HbA1c 6.5% - 10.0% (47 - 86 mmol/mol) (both inclusive) (latest available and no more than 30 days old local laboratory assessment based on medical records or point of care measurement)
-
At least one of the below conditions (a-d):
a) Coronary heart disease defined as at least one of the following: i. Prior myocardial infarction ii. Prior coronary revascularisation procedure iii. 50% or above stenosis in coronary artery documented by cardiac catheterisation, computerized tomography coronary angiography iv. Coronary heart disease with ischaemia documented by stress test with any imaging modality b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke ii. Prior carotid artery revascularisation procedure iii.50% or above stenosis in carotid artery documented by X-ray angiography, magnetic resonance angiography, computerized tomography angiography or Doppler ultrasound c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an Ankle-brachial index (ABI) below 0.85 at rest ii. Intermittent claudication with a 50% or above stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, magnetic resonance angiography, computerized tomography angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularization procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis) d) Chronic kidney disease defined as: i. eGFR below 60 mL/min/1.73 m^2 (based on medical records using latest available and no more than 6 months old assessment)
- Any of the following: myocardial infarction, stroke, hospitalisation for unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the day of screening
- Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
- Heart failure presently classified as being in New York Heart Association Class IV
- Treatment with any glucagon-like peptide-1 receptor agonist within 30 days before screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo (semaglutide) One tablet daily for 3.5 to 5 years Oral semaglutide Semaglutide One tablet daily for 3.5 to 5 years
- Primary Outcome Measures
Name Time Method Time to first occurrence of a major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death/non-fatal myocardial infarction/non-fatal stroke From randomisation (week 0) to end-of-trial (up to 61 months or more) (trial is event driven) Months
- Secondary Outcome Measures
Name Time Method Time to first occurrence of a composite CKD endpoint From randomisation (week 0) to end-of-trial (up to 61 months or more) Time to first occurrence of a composite CKD endpoint consisting of: renal death/onset of persistent 50% or more reduction in eGFR (CKD-EPI)/onset of persistent eGFR (CKD-EPI) below 15 mL/min/1.73 m\^2/initiation of chronic renal replacement therapy (dialysis or kidney transplantation).
Unit of assessment: MonthsTime to first occurrence of non-fatal stroke From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Annual rate of change in eGFR (CKD-EPI) (total eGFR slope) From randomisation (week 0) to end-of-trial (up to 61 months or more) ml/min/1.73 m\^2 per year
Time to occurrence of renal death From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to occurrence of CV death From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of onset of persistent eGFR (CKD-EPI) below 15 mL/min/1.73 m^2 From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of initiation of chronic renal replacement therapy (dialysis or kidney transplantation) From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of a composite endpoint consisting of: all-cause death/non-fatal myocardial infarction/non-fatal stroke From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of a composite endpoint From randomisation (week 0) to end-of-trial (up to 61 months or more) Time to first occurrence of a composite endpoint consisting of: CV death/renal death/onset of persistent 50% or more reduction in estimated glomerular filtration rate (eGFR) (chronic kidney disease - epidemiology collaboration (CKD-EPI)) (compared with baseline)/onset of persistent eGFR (CKD-EPI) below 15 mL/min/1.73 m\^2/initiation of chronic renal replacement therapy (dialysis or kidney transplantation).
Unit of assessment: MonthsTime to first occurrence of a composite heart failure endpoint consisting of: CV death/heart failure requiring hospitalisation/urgent heart failure visit From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of major adverse limb events (MALE), a composite endpoint consisting of: acute limb ischemia hospitalisation/chronic limb ischemia hospitalisation From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of non-fatal myocardial infarction (MI) From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of heart failure requiring hospitalisation From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of coronary revascularisation From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of unstable angina requiring hospitalisation From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of acute limb ischemia From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of chronic limb ischemia From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Change in body weight From randomisation (week 0) to 2 years Kilograms
Number of severe hypoglycaemic episodes From randomisation (week 0) to end-of-trial (up to 61 months or more) Number of events
Time to first occurrence of an expanded MACE composite endpoint consisting of: CV death/non-fatal myocardial infarction/ non-fatal stroke/coronary revascularisation/unstable angina requiring hospitalisation From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to occurrence of all-cause death From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of urgent heart failure visit From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Time to first occurrence of onset of persistent 50% or more reduction in eGFR From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Change in glycosylated haemoglobin (HbA1c) From randomisation (week 0) to 2 years Percent points
Time to first occurrence of a severe hypoglycaemic episode From randomisation (week 0) to end-of-trial (up to 61 months or more) Months
Trial Locations
- Locations (464)
Eskisehir Osmangazi University School of Medicine
🇹🇷Eskisehir, Turkey
Haseki Egitim ve Arastirma Hastanesi_ISTANBUL
🇹🇷Istanbul, Turkey
Kanuni Sultan Suleyman Egitim ve Arastirma Hastanesi
🇹🇷Istanbul, Turkey
Dokuz Eylul University Medical Faculty
🇹🇷Izmir, Turkey
RMI "Chernivtsi Regional Endocrinology Centre"
🇺🇦Chernivtsi, Ukraine
Hatay Mustafa Kemal Universitesi Saglik Uygulama ve Arastirm
🇹🇷Hatay, Turkey
Nemocnica akademika L. Derera, UNB
🇸🇰Bratislava, Slovakia
HUMAN-CARE s.r.o.
🇸🇰Kosice, Slovakia
CARDIO D&R, s.r.o.
🇸🇰Kosice, Slovakia
Deepak Lakha
🇿🇦Johannesburg, Gauteng, South Africa
Hemant Makan
🇿🇦Johannesburg, Gauteng, South Africa
Dr H Bacus
🇿🇦Berea, KwaZulu-Natal, South Africa
Dr A Amod
🇿🇦Durban, KwaZulu-Natal, South Africa
Bursa Il Saglik Mudurlugu Yuksek Ihtısas Egitim ve Arastirma Hastanesi
🇹🇷Bursa, Turkey
T.C. Saglik Bakanligi Bursa Il Saglik Mudurlugu Yuksek Ihtıs
🇹🇷Bursa, Turkey
Ataturk Universitesi Tip Fakultesi
🇹🇷Erzurum, Turkey
North Manchester General Hospital - Diabetes Centre
🇬🇧Manchester, United Kingdom
UT Southwestern Med Cntr
🇺🇸Dallas, Texas, United States
Diabetes and Thyroid Ctr of FW
🇺🇸Fort Worth, Texas, United States
PrimeCare Medical Group
🇺🇸Houston, Texas, United States
Synergy Groups Medical
🇺🇸Houston, Texas, United States
DCOL Ctr for Clin Res
🇺🇸Longview, Texas, United States
Midland Clinical Research Center
🇺🇸Midland, Texas, United States
Simcare Medical Research, LLC
🇺🇸Sugar Land, Texas, United States
Hillcrest Family Health Center
🇺🇸Waco, Texas, United States
Imeldaziekenhuis - Bonheiden - Department of Endocrinology
🇧🇪Bonheiden, Belgium
UZ Antwerpen - UZA - Department of Endocrinology
🇧🇪Edegem, Belgium
UZA - UZ Antwerpen - Department of Endocrinology
🇧🇪Edegem, Belgium
UZ Gent - Endocrinologie - Diabetologie
🇧🇪Gent, Belgium
AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie
🇧🇪Kortrijk, Belgium
LMC ClinRsrh Inc.Brampton
🇨🇦Brampton, Ontario, Canada
Aggarwal and Assoc Ltd.
🇨🇦Brampton, Ontario, Canada
Apollo Excelcare Hospital, Guwahati
🇮🇳Guwahati, Assam, India
Apollo Excelcare Hospital
🇮🇳Guwahati, Assam, India
HCG Hospitals
🇮🇳Ahmedabad, Gujarat, India
Apollo Multispeciality Hospital, Kolkata
🇮🇳Kolkata, West Bengal, India
Lady Hardinge Medical College
🇮🇳New Delhi, India
Jothydev's Diabetes & Research Center
🇮🇳Thriruvananthapuram, India
Diabetes and obesity center of excellence, Rambam MC
🇮🇱Haifa, Israel
Diabetes Unit Hadassah Ein Karem MC
🇮🇱Jerusalem, Israel
Endocrinology & Diabetes Clinic Clalit Jerusalem
🇮🇱Jerusalem, Israel
Clinical Research Unit Meir Medical Center
🇮🇱Kfar Saba, Israel
Institute of Diabetes, Western Galilee MC Nahariya
🇮🇱Nahariya, Israel
Rabin MC Beilinson Campus Endo
🇮🇱Petah-Tikva, Israel
Endrocrinolgy Clinic - Sheba Medical Center
🇮🇱Tel Hashomer, Israel
Sheba Medica Center - Clinical Research Unit
🇮🇱Tel Hashomer, Israel
Institute of Endocrinology, metabolism and hypertension
🇮🇱Tel-Aviv, Israel
A.O.U. Consorziale Policlinico di Bari
🇮🇹Bari, BA, Italy
Hanaoka Seishu Memorial Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Kagawa Prefectural Central Hospital, Cardiovascular Medicine
🇯🇵Takamatsu-shi, Kagawa, Japan
Oyama East Clinic
🇯🇵Tochigi, Japan
Tokorozawa Heart Center
🇯🇵Tokorozawa-shi, Saitama, Japan
Tokyo Nishi Tokushukai Hospital
🇯🇵Tokyo, Japan
Maastricht Universitair Medisch Centrum
🇳🇱Maastricht, Netherlands
Radboudumc
🇳🇱Nijmegen, Netherlands
Universitair Medisch Centrum Utrecht
🇳🇱Utrecht, Netherlands
Clinic of Diabetes Cluj
🇷🇴Cluj Napoca, Cluj, Romania
Complejo Hospitalario Universitario A Coruña
🇪🇸La Coruña, Spain
Gulhane Egitim Arastirma Hastanesi
🇹🇷Ankara, Turkey
KBC Rijeka, Zavod za endokrinologiju
🇭🇷Rijeka, Croatia
KBC Split / Krizine / Dijabetes
🇭🇷Split, Croatia
Opca bolnica Varazdin
🇭🇷Varazdin, Croatia
Opca bolnica Zadar
🇭🇷Zadar, Croatia
KB Merkur - Sveucilisna klinika Vuk Vrhovac
🇭🇷Zagreb, Croatia
KB Dubrava, Zavod za endokrinologiju i dijabetes
🇭🇷Zagreb, Croatia
University Hospital U sv. Anny
🇨🇿Brno, Czechia
Intendia klinika
🇨🇿Chrudim, Czechia
FN Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Metabolicke Centrum MUDr. Katariny Raslovej s.r.o.
🇸🇰Bratislava, Slovakia
MediTask, s.r.o
🇸🇰Bratislava, Slovakia
Nemocnica Krompachy spol. s r.o Diabetol. amb. MD Gmitrov
🇸🇰Krompachy, Slovakia
Diabetologicka ambulancia MUDr. Katarina Plevova, s.r.o.
🇸🇰Nitra, Slovakia
DENTAVIA s.r.o.
🇸🇰Poprad, Slovakia
MUDr. Jan Culak, s.r.o.
🇸🇰Prievidza, Slovakia
Kardiologicka a interna ambulancia
🇸🇰Rimavska Sobota, Slovakia
Tatratrial s.r.o.
🇸🇰Roznava, Slovakia
IRIDIA s.r.o.
🇸🇰Vrutky, Slovakia
Diabetes Care Centre & CDE Centre
🇿🇦Benoni, Gauteng, South Africa
Peermed Clinical Trial Centre
🇿🇦Johannesburg, Gauteng, South Africa
Soweto Clinical Trial Centre
🇿🇦Johannesburg, Gauteng, South Africa
Centre for Diabetes
🇿🇦Johannesburg, Gauteng, South Africa
Dr Seeber
🇿🇦Pretoria, Gauteng, South Africa
Prof P. Joshi
🇿🇦Pretoria, Gauteng, South Africa
Dr T Padayachee
🇿🇦Durban, KwaZulu-Natal, South Africa
Dr Pillay's Rooms
🇿🇦Durban, KwaZulu-Natal, South Africa
Diabetes Clinical Trials Unit
🇿🇦Cape Town, Western Cape, South Africa
UCT Clinical Research Centre
🇿🇦Cape Town, Western Cape, South Africa
Hospital Fundación Alcorcón
🇪🇸Alcorcón, Madrid, Spain
Hospital Comarcal de Antequera
🇪🇸Antequera, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Público da Mariña
🇪🇸Burela, Spain
Hospital Reina Sofia
🇪🇸Córdoba, Spain
Hospital Universitario de Gran Canaria Doctor Negrín
🇪🇸Las Palmas de Gran Canaria, Spain
Hospital Ribera Polusa
🇪🇸Lugo, Spain
Hospital Clínico Virgen de la Victoria
🇪🇸Málaga, Spain
Hospital Quirón
🇪🇸Pozuelo de Alarcon, Spain
Hospital Virgen del Camino - Sanlúcar de Barrameda
🇪🇸Sanlúcar de Barrameda, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Complejo Hospitalario Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Virgen de la Macarena
🇪🇸Sevilla, Spain
Changhua Christian Hospital
🇨🇳Changhua City, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung City, Taiwan
Chang Gung Medical Foundation - Linkou Branch
🇨🇳Taoyuan city, Taiwan
Siriraj Hospital_Bangkoknoi, Bangkok
🇹🇭Bangkoknoi, Bangkok, Bangkok, Thailand
Songklanagarind Hospital
🇹🇭Songkla, Had-Yai, Thailand
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Mueang Chiang Mai, Thailand
King Chulalongkorn Memorial Hospital_Bangkok
🇹🇭Bangkok, Thailand
Police General Hospital
🇹🇭Bangkok, Thailand
Phramongkutklao Hospital
🇹🇭Bangkok, Thailand
Rajavithi Hospital
🇹🇭Bangkok, Thailand
Ramathibodi Hospital-Cardiovascular metabolic Center
🇹🇭Bangkok, Thailand
Siriraj Hospital_Bangkok_1
🇹🇭Bangkok, Thailand
Maharat Nakhon Ratchasima Hospital
🇹🇭Nakhon Ratchasima, Thailand
T.C. Saglık Bakanlıgı Adana Sehir Egitim ve Arastirma Hastan
🇹🇷Adana, Turkey
T.C SB Goztepe Prof. Dr. Suleyman Yalcin City Hospital
🇹🇷Istanbul, Turkey
Sivas Cumhuriyet Univesity Endocrinology Department
🇹🇷Sivas, Turkey
Erciyes Universitesi Tip Fakultesi
🇹🇷Kayseri, Turkey
Karadeniz University School of Medicine-Adult Endocrinology
🇹🇷Trabzon, Turkey
Cherkasy Regional Hospital of Cherkasy Reg. Council
🇺🇦Cherkasy, Ukraine
CI Dnipropetrovsk Regional Hospital
🇺🇦Dnipro, Ukraine
Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
🇺🇦Kyiv, Ukraine
SRI "Centre of Innovative Medical Technologies of the NASU"
🇺🇦Kyiv, Ukraine
Transcarpathian Regional Clinical Hospital of A. Novak
🇺🇦Uzhhorod, Ukraine
Lviv Regional Endocrinology Diagnostic and Treatment Centre
🇺🇦Lviv, Ukraine
Odesa Regional Clinical Hospital
🇺🇦Odesa, Ukraine
CI "1st City Clinical Hospital of Poltava City Council"
🇺🇦Poltava, Ukraine
Zhytomir Regional Clinical Hospital
🇺🇦Zhytomyr, Ukraine
Crouch Oak Family Practice
🇬🇧Addlestone, Surrey, United Kingdom
Aberdeen Royal Infirmary
🇬🇧Aberdeen, United Kingdom
Royal Victoria Hospital
🇬🇧Belfast, United Kingdom
The Health Centre
🇬🇧Bradford-on-Avon, United Kingdom
Southmead Hospital
🇬🇧Bristol, United Kingdom
Addenbrooke's Hospital_Cambridge
🇬🇧Cambridge, United Kingdom
Hathaway Surgery
🇬🇧Chippenham, United Kingdom
WISDEM Centre
🇬🇧Coventry, United Kingdom
Western General Hospital
🇬🇧Edinburgh, United Kingdom
Glasgow Clinical Research Facility
🇬🇧Glasgow, United Kingdom
Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
Harrogate District Hospital
🇬🇧Harrogate, United Kingdom
Burbage Surgery
🇬🇧Hinckley, United Kingdom
Hull Royal Infirmary
🇬🇧Hull, United Kingdom
Royal Free - Diabetes
🇬🇧London, United Kingdom
The Norfolk and Norwich University Hospital
🇬🇧Norfolk, United Kingdom
University Dept of Medicine, Derriford Hospital, Plymouth
🇬🇧Plymouth, United Kingdom
East Surrey Hospital
🇬🇧Redhill, United Kingdom
The Staploe Medical Centre
🇬🇧Soham, United Kingdom
Joint Clinical Research Facility - Swansea
🇬🇧Swansea, United Kingdom
Healthscan Clinical Trials,LLC.
🇺🇸Montgomery, Alabama, United States
Medical Investigations, Inc.
🇺🇸Little Rock, Arkansas, United States
Unity Health-Searcy Medical Center
🇺🇸Searcy, Arkansas, United States
B&K Medical Research Center
🇺🇸Fresno, California, United States
Scripps Whittier Diabetes Inst
🇺🇸La Jolla, California, United States
Diabetes & Endocrine Associates
🇺🇸La Mesa, California, United States
First Valley Medical Group
🇺🇸Lancaster, California, United States
Pacific Clinical Studies
🇺🇸Los Alamitos, California, United States
Facey Medical Foundation
🇺🇸Mission Hills, California, United States
Monterey Endocrine & Diabetes Institute, Inc
🇺🇸Monterey, California, United States
Desert Oasis Hlthcr Med Group
🇺🇸Palm Springs, California, United States
San Diego Family Care
🇺🇸San Diego, California, United States
Lundquist Inst-Biomed Innovtn
🇺🇸Torrance, California, United States
Coastal Metabolic Research Center
🇺🇸Ventura, California, United States
Rocky Mount Reg VA Med-DN
🇺🇸Aurora, Colorado, United States
Creekside Endocrine Associates, PC
🇺🇸Denver, Colorado, United States
New West Physicians,Inc.
🇺🇸Golden, Colorado, United States
East Coast Medical Associates, Inc.
🇺🇸Boca Raton, Florida, United States
Suncoast Clin Res Port Richey
🇺🇸New Port Richey, Florida, United States
AdventHealth Diab Inst
🇺🇸Orlando, Florida, United States
Ellipsis Group
🇺🇸Alpharetta, Georgia, United States
Physicians Research Assoc. LLC
🇺🇸Lawrenceville, Georgia, United States
Endo Res Solutions Inc
🇺🇸Roswell, Georgia, United States
East West Med Res Inst
🇺🇸Honolulu, Hawaii, United States
Rocky Mountain Diab&Osteo Ctr
🇺🇸Idaho Falls, Idaho, United States
Clinical Invest Special_Gurnee
🇺🇸Gurnee, Illinois, United States
American Health Network of IN LLC_Franklin
🇺🇸Franklin, Indiana, United States
American Health Network of Indiana, LLC_Greenfield
🇺🇸Greenfield, Indiana, United States
Franciscan Health Michigan City
🇺🇸Michigan City, Indiana, United States
American Health Network of IN LLC
🇺🇸Muncie, Indiana, United States
Iowa Diab & Endo Res Center
🇺🇸West Des Moines, Iowa, United States
The Research Group of Lexington LLC
🇺🇸Lexington, Kentucky, United States
Robley Rex VA Medical Center
🇺🇸Louisville, Kentucky, United States
L-MARC Research Center
🇺🇸Louisville, Kentucky, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Ileana J Tandron APMC
🇺🇸Slidell, Louisiana, United States
Northern Pines Hlth Ctr, PC
🇺🇸Buckley, Michigan, United States
Methodist Phys. Clinic
🇺🇸Omaha, Nebraska, United States
Univ of Nebraska Medical CTR
🇺🇸Omaha, Nebraska, United States
Palm Research Center Inc-Vegas
🇺🇸Las Vegas, Nevada, United States
Dartmouth-Hitchcock Med Ctr
🇺🇸Lebanon, New Hampshire, United States
Southern New Hampshire Diabetes and Endocrinology
🇺🇸Nashua, New Hampshire, United States
Albany Medical College - Endo
🇺🇸Albany, New York, United States
Southgate Medical Group, LLP
🇺🇸West Seneca, New York, United States
Mountain Diabetes & Endocrine Center
🇺🇸Asheville, North Carolina, United States
Eastern Nephr Assoc, PLLC
🇺🇸New Bern, North Carolina, United States
Lillestol Research LLC
🇺🇸Fargo, North Dakota, United States
Your Diabetes Endocrine Nutrition Group, Inc.
🇺🇸Mentor, Ohio, United States
Great Lakes Medical Research
🇺🇸Westfield, New York, United States
PharmQuest Life Sciences LLC
🇺🇸Greensboro, North Carolina, United States
Physicians East Endocrinology
🇺🇸Greenville, North Carolina, United States
Twinsburg Family Health Center
🇺🇸Twinsburg, Ohio, United States
Heritage Valley Medical Group Inc
🇺🇸Beaver, Pennsylvania, United States
Kernodle Clin Dpt-Pvt Diagnost
🇺🇸Burlington, North Carolina, United States
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Whiteville Medical Associates
🇺🇸Whiteville, North Carolina, United States
Advanced Med Res Maumee
🇺🇸Maumee, Ohio, United States
Accellacare
🇺🇸Wilmington, North Carolina, United States
Lynn Institute of Norman
🇺🇸Norman, Oklahoma, United States
Primary Care Research South, Inc
🇺🇸McMurray, Pennsylvania, United States
Aria Endocrine Metabolic Assoc
🇺🇸Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians Inc.
🇺🇸Pittsburgh, Pennsylvania, United States
The Diabetes Center, LLC
🇺🇸Murrells Inlet, South Carolina, United States
Carolina Health Specialists
🇺🇸Myrtle Beach, South Carolina, United States
Spartanburg Medical Research
🇺🇸Spartanburg, South Carolina, United States
Michael L Reeves, MD
🇺🇸Chattanooga, Tennessee, United States
Univ Diab & Endo Consultants
🇺🇸Chattanooga, Tennessee, United States
Holston Medical Group
🇺🇸Kingsport, Tennessee, United States
InvestiClin Research
🇺🇸Nashville, Tennessee, United States
MidState Endocrine Associates
🇺🇸Nashville, Tennessee, United States
Vanderbilt Diab Obes Clin Tri
🇺🇸Nashville, Tennessee, United States
Trinity Clinical Research LLC
🇺🇸Tullahoma, Tennessee, United States
Arlington Family Res. Ctr Inc
🇺🇸Arlington, Texas, United States
Central Texas Clinical Research
🇺🇸Austin, Texas, United States
Texas Diabetes & Endocrinology, P.A._Austin
🇺🇸Round Rock, Texas, United States
Texas Diabetes & Endocrinology
🇺🇸Austin, Texas, United States
Velocity Clinical Res-Dallas
🇺🇸Dallas, Texas, United States
University of Vermont Medical Center
🇺🇸South Burlington, Vermont, United States
Dominion Medical Associates
🇺🇸Richmond, Virginia, United States
Selma Medical Associates
🇺🇸Winchester, Virginia, United States
Clinical Inv Spec, Inc.Kenosha
🇺🇸Kenosha, Wisconsin, United States
Internal medicine department
🇩🇿Algiers, Algeria
endocrino-diabetology department, Hospital IBN BADIS.
🇩🇿Constantine, Algeria
Internal Medecine department CHU Ibn Badis
🇩🇿Constantine, Algeria
EHU 1st November 1954
🇩🇿Oran, Algeria
Internal Medicine departement CHU Oran
🇩🇿Oran, Algeria
Department of internal of medicine, CHU Setif
🇩🇿Setif, Algeria
Centro Médico CIMEL
🇦🇷Lanus Este, Argentina
DIM Clinica Privada
🇦🇷Buenos Aires, Argentina
Centro Medico Lebensohn
🇦🇷Buenos Aires, Argentina
Hospital Italiano
🇦🇷Buenos Aires, Argentina
Centro de Investigaciones Metabólicas
🇦🇷Capital Federal, Argentina
Centro Diabetologico Cordoba Dr. Waitman
🇦🇷Cordoba, Argentina
Centro médico privado Cemaic
🇦🇷Córdoba, Argentina
Instituto Médico DAMIC
🇦🇷Córdoba, Argentina
Centro Médico Privado San Vicente Diabetes
🇦🇷Córdoba, Argentina
Instituto de Investigaciones Clinicas
🇦🇷Mar del Plata, Argentina
Sanatorio Britanico S.A.
🇦🇷Rosario, Santa Fe, Argentina
Univ.-Klinik für Innere Medizin
🇦🇹Graz, Austria
Medizinische Universität Innsbruck
🇦🇹Innsbruck, Austria
Fließer-Görzer [Ordination]
🇦🇹Saint Stefan, Austria
Klinik Hietzing
🇦🇹Wien, Austria
Klinik Ottakring
🇦🇹Wien, Austria
UZ Leuven - Endocrinology
🇧🇪Leuven, Belgium
AZ Delta - Roeselare - Diabeteskliniek
🇧🇪Roeselare, Belgium
AZ Delta - Roeselare
🇧🇪Roeselare, Belgium
Hospital do Coração do Brasil
🇧🇷Brasilia, Distrito Federal, Brazil
Cline Research Center
🇧🇷Curitiba, Parana, Brazil
Quanta Diagnóstico Nuclear / Medicina Nuclear Alto da XV
🇧🇷Curitiba, Parana, Brazil
Hospital São Vicente de Paulo
🇧🇷Passo Fundo, Rio Grande Do Sul, Brazil
CPQuali Pesquisa Clínica Ltda
🇧🇷São Paulo, Sao Paulo, Brazil
C-endo Diab Endo Clin Calgery
🇨🇦Calgary, Alberta, Canada
Instituto de Pesquisa Clínica de Campinas
🇧🇷Campinas, Sao Paulo, Brazil
Vancouver General Hospital_Vancouver_0
🇨🇦Vancouver, British Columbia, Canada
i9 Pesquisas Clínicas
🇧🇷Campinas, Sao Paulo, Brazil
Instituto de Pesquisa Clinica (IPEC)
🇧🇷São Paulo, Sao Paulo, Brazil
CPCLIN - Centro de Pesquisas Clínicas
🇧🇷São Paulo, Sao Paulo, Brazil
Nova Scotia Hlth Halifax
🇨🇦Halifax, Nova Scotia, Canada
LMC Diabetes & Endocrinology (Barrie)
🇨🇦Barrie, Ontario, Canada
LMC Clinical Res Thornhill
🇨🇦Concord, Ontario, Canada
McMaster University
🇨🇦Hamilton, Ontario, Canada
Bluewater Clin Res Group, Inc.
🇨🇦Sarnia, Ontario, Canada
Bluewater Clin Res Group,Inc
🇨🇦Sarnia, Ontario, Canada
St. Michael's Hospital
🇨🇦Toronto, Ontario, Canada
UHN-Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
Premier Clinical Trial Research Network (PCTRN)
🇨🇦Hamilton, Ontario, Canada
Diabetes Heart Research Centre
🇨🇦Toronto, Ontario, Canada
Manna Research Mirabel
🇨🇦Mirabel, Quebec, Canada
Applied Med Inf Res
🇨🇦Montreal, Quebec, Canada
CHU de Quebec-Universite Laval
🇨🇦Quebec, Canada
Peking University People's Hospital-Endocrinology
🇨🇳Beijing, Beijing, China
Cangzhou People's Hospital-Endocrinology
🇨🇳Cangzhou, Hebei, China
Cangzhou People's Hospital
🇨🇳Cangzhou, Hebei, China
Changzhou No.2 People's Hospital, Yanghu Branch
🇨🇳Changzhou, Jiangsu, China
The Affiliated Hospital of Jiangsu University-Endocrinology
🇨🇳Zhenjiang, Jiangsu, China
The Affiliated Hospital of Jiangsu University_Zhenjiang
🇨🇳Zhenjiang, Jiangsu, China
Jinan Central Hospital
🇨🇳Ji'nan, Shandong, China
Jinan Central Hospital Affiliated to Shandong University
🇨🇳Jinan, Shandong, China
Shanghai Fifth People's Hospital-Endocrinology
🇨🇳Shanghai, Shanghai, China
Clinica de la Costa
🇨🇴Barranquilla, Colombia
Fundación Hospital Universidad del Norte
🇨🇴Soledad, Barranquilla, Colombia
Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia
🇨🇴Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander, Colombia
Fundacion Valle del Lili
🇨🇴Cali, Valle Del Cauca, Colombia
Fundación Centro de Obesidad y Metabolismo COMETA
🇨🇴Pasto, Colombia
Poliklinika Solmed
🇭🇷Zagreb, Grad Zagreb, Croatia
Specijalna bolnica Krapinske Toplice - Endokrinologija
🇭🇷Krapinske Toplice, Croatia
Klinicki bolnicki centar Osijek
🇭🇷Osijek, Croatia
Opca bolnica Pula
🇭🇷Pula, Croatia
Diabetologicka a Interni Ambulance MUDr. Jan Vrkoc s.r.o.
🇨🇿Moravska Ostrava, Czechia
Ambulance DIA - INTERNA s.r.o.
🇨🇿Ostrava, Czechia
Diabetologicka ambulance Plzen
🇨🇿Plzen, Czechia
MUDr. Jitka Zemanova diabetologie a interna
🇨🇿Plzeň - Východní Předměstí, Czechia
DIALINE s.r.o.
🇨🇿Plzeň 3, Czechia
Institut klinicke a experimentalni mediciny_Praha
🇨🇿Praha, Czechia
Aarhus Universitetshospital, Steno Diabetes Center Aarhus
🇩🇰Aarhus N, Denmark
Hillerød Endokrinologisk amb. H0652
🇩🇰Hillerød, Denmark
Bispebjerg Hospital, IC-Forskning
🇩🇰København, Denmark
Slagelse Sygehus Ambulatorium for hjertesygdomme
🇩🇰Slagelse, Denmark
Svendborg Sygehus
🇩🇰Svendborg, Denmark
Centre Hospitalier Universitaire de Besancon-Hopital Jean Minjoz
🇫🇷Besançon cedex, France
Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
🇫🇷DIJON cedex, France
Les Hopitaux de Chartres-Hopital Louis Pasteur
🇫🇷Le Coudray, France
Assistance Publique Hopitaux de Marseille-Hopital de La Conception
🇫🇷Marseille, France
Centre Hospitalier de Narbonne
🇫🇷Narbonne, France
Ap-Hp-Hopital Bichat-Claude Bernard-1
🇫🇷Paris, France
Centre Hospitalier Universitaire de Bordeaux-Hopital Haut Leveque-2
🇫🇷Pessac, France
Les Hopitaux Universitaires de Strasbourg-Hopital de Hautepierre-1
🇫🇷Strasbourg, France
MVZ "Am Felsenkeller" (Dresden)
🇩🇪Dresden, Germany
Uniklinik TU Dresden Med. Klinik III
🇩🇪Dresden, Germany
Praxis Dr. med. M. Esser
🇩🇪Essen, Germany
Zentrum für klinische Forschung, Dr. med. Lüdemann
🇩🇪Falkensee, Germany
Diabetologische Schwerpunktpraxis Harburg - Dr. med.Paschen, Hamburg
🇩🇪Hamburg, Germany
Diabetes Zentrum Wandsbek Berufsausuebungsgemeinschaft GbR
🇩🇪Hamburg, Germany
Praxisgemeinschaft Jerichow
🇩🇪Jerichow, Germany
Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz
🇩🇪Lingen, Germany
Die Praxis am Ludwigsplatz
🇩🇪Ludwigshafen, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
🇩🇪Münster, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
🇩🇪Oldenburg in Holstein, Germany
Praxis Dr. med. Wenzl-Bauer
🇩🇪Rehlingen-Siersburg, Germany
Marienhospital Stuttgart - Innere Medizin 1
🇩🇪Stuttgart, Germany
Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann
🇩🇪Witten, Germany
Prince of Wales Hospital
🇭🇰Shatin, New Territories, Hong Kong
Dr. Jivraj Mehta Health Foundation
🇮🇳Ahmedabad, Gujarat, India
PGIMS Rohtak
🇮🇳Rohtak, Haryana, India
Osmania General Hospital
🇮🇳Hyderabad, Telangana, India
Sunshine Hospital
🇮🇳Hyderabad, Andhra Pradesh, India
Care Outpatient Centre
🇮🇳Hyderabad, Andhra Pradesh, India
Ramdev Rao Hospital
🇮🇳Hyderabad, Telangana, India
Ramaiah Memorial Hospital
🇮🇳Bangalore, Karnataka, India
Lifecare Hospital and Research Centre
🇮🇳Bangalore, Karnataka, India
Calicut Medical College
🇮🇳Kozhikode, Kerala, India
TOTALL Diabetes Hormone Institute
🇮🇳Indore, Madhya Pradesh, India
P D Hinduja National Hospital and Medical Research Centre
🇮🇳Mumbai, Maharashtra, India
BYL Nair Hospital and T N Medical College Department of endo
🇮🇳Mumbai, Maharashtra, India
BSES MG hospital
🇮🇳Mumbai, Maharashtra, India
Fortis Hospital Mulund
🇮🇳Mumbai, Maharashtra, India
Fortis Hospital, Mulund, Mumbai
🇮🇳Mumbai, Maharashtra, India
chelleram Diabetes Institute
🇮🇳Pune, Maharashtra, India
Inamdar Multispeciality Hospital
🇮🇳Pune, Maharashtra, India
All India Institute of Medical Sciences
🇮🇳New Dehli, New Delhi, India
Kanungo Institute of Diabetes Specialities Pvt Ltd
🇮🇳Bhubaneswar, Orissa, India
Dayanand Medical College & Hospital
🇮🇳Ludhiana, Punjab, India
Christian Medical College and Hospital
🇮🇳Ludhiana, Punjab, India
Fortis Heart Institute and Multispeciality Hospital
🇮🇳Mohali, Punjab, India
Diabetes, Thyroid and Endocrine Centre
🇮🇳Jaipur, Rajasthan, India
Madras Diabetes Research Foundation
🇮🇳Chennai, Tamil Nadu, India
Kg Hospital and Post Graduate Medical Institute
🇮🇳Coimbatore, Tamil Nadu, India
Christian Medical College Hospital, Vellore
🇮🇳Vellore, Tamil Nadu, India
Gandhi Hospital & Medical college
🇮🇳Hyderabad, Telengana, India
SSKM
🇮🇳Kolkata, West Bengal, India
Apollo Gleneagles Hospital
🇮🇳Kolkata, West Bengal, India
Azienda Ospedaliero-Universitaria Renato Dulbecco
🇮🇹Catanzaro, Cz, Italy
Ospedale Civile Campo di Marte
🇮🇹Lucca, LU, Italy
Istituto Scientifico San Raffaele
🇮🇹Milano, MI, Italy
Policlinico Umberto I Seconda Clinica Medica
🇮🇹Roma, RM, Italy
Azienda Ospedaliera di Perugia;Ospedale S. Maria della Misericordia
🇮🇹Perugia, Umbria, Italy
Università degli studi G. D'Annunzio Chieti Pescara - CAST
🇮🇹Chieti Scalo, Italy
Centro Cardiologico Monzino. Istituto di Ricovero e Cura
🇮🇹Milano, Italy
Università Federico II Dip. di Med. Clinica e Chirurgia Ed 1
🇮🇹Napoli, Italy
Azienda Ospedaliera di Padova Malatt.Metab
🇮🇹Padova, Italy
Dip. di Medicina Interna Policlinico Universitario Palermo
🇮🇹Palermo, Italy
Policlinico Universitario Paolo Giaccone
🇮🇹Palermo, Italy
Jinnouchi Hospital
🇯🇵Kumamoto-shi, Kumamoto, Japan, Japan
Heiwadai Hospital
🇯🇵Miyazaki-shi, Miyazaki, Japan
The University of Tokyo Hospital, Diabetes and Metabolic
🇯🇵Bunkyo-ku, Tokyo, Japan
New Tokyo Heart Clinic_Matsudo-shi, Chiba,
🇯🇵Chiba, Japan
Ehime Prefectural Central Hospital
🇯🇵Ehime, Japan
Fukui Prefectural Hospital
🇯🇵Fukui, Japan
Fukuoka Tokushukai Hospital
🇯🇵Fukuoka, Japan
Naka Kinen Clinic
🇯🇵Ibaraki, Japan
Kyoto University Hospital
🇯🇵Kyoto-shi, Kyoto, Japan
Uji Tokushukai Medical Center
🇯🇵Kyoto, Japan
Shinden Higashi Clinic_Miyagi
🇯🇵Miyagi, Japan
Shinshu University Hospital
🇯🇵Nagano, Japan
Saiseikai Suita Hospital
🇯🇵Osaka, Japan
Osaka University Hospital_Osaka
🇯🇵Osaka, Japan
Takatsuki Red Cross Hospital
🇯🇵Osaka, Japan
Nozaki Tokushukai Hospital
🇯🇵Osaka, Japan
Saga University Hospital, Department of Cardiology
🇯🇵Saga-shi, Saga, Japan
Tokyo-Eki Center-building Clinic
🇯🇵Tokyo, Japan
Juntendo University Hospital_Tokyo
🇯🇵Tokyo, Japan
Juntendo University Hospital
🇯🇵Tokyo, Japan
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Hanyang University GURI Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Sugawara Clinic
🇯🇵Tokyo, Japan
Minamino Cardiovascular Hospital
🇯🇵Tokyo, Japan
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Nowon Eulji Medical Center, Eulji University
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul Saint Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Hospital Sultanah Bahiyah
🇲🇾Alor Setar, Malaysia
Hospital Raja Perempuan Zainab II
🇲🇾Kota Bharu, Kelantan, Malaysia
Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan
🇲🇾Kota Bharu, Kelantan, Malaysia
Sarawak Heart Centre
🇲🇾Kota Samarahan, Sarawak, Malaysia
University Technology MARA (UiTM) - Puncak Alam
🇲🇾Sungai Buloh, Selangor, Malaysia
University Technology MARA (UiTM) - Sg Buloh
🇲🇾Sungai Buloh, Selangor, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Hospital Putrajaya
🇲🇾Wilayah Persekutuan Putrajaya, Malaysia
Sarawak General Hospital
🇲🇾Kuching, Malaysia
Hospital Miri
🇲🇾Sarawak, Malaysia
Hospital Tuanku Jaafar
🇲🇾Seremban, Malaysia
Inst. Jaliscience de Investigacion en Diabetes y Obesidad SC
🇲🇽Guadalajara, Jalisco, Mexico
Arechavaleta Granell María del Rosario
🇲🇽Guadalajara, Jalisco, Mexico
Centro de Atención Integral al Paciente con Diabetes
🇲🇽Tlalpan, México, D.F., Mexico
Cardiolink Clin Trials S.C.
🇲🇽Monterrey, Nuevo Leon, Mexico
Internal Medicine Clin Trials
🇲🇽Monterrey, Nuevo León, Mexico
Unidad Medica para la Salud Integral (UMSI)
🇲🇽San Nicolas de los Garza, Nuevo León, Mexico
Investigación Médica Sonora S.C.
🇲🇽Hermosillo, Sonora, Mexico
Medical Care and Research S. A de C.V
🇲🇽Merida, Yucatan, Mexico
Centro de Desarrollo Biomédico S.C.P.
🇲🇽Mérida, Yucatan, Mexico
EME Red Hospitalaria
🇲🇽Mérida, Yucatán, Mexico
Centro de Investigación Cardiometabólica de Aguascalientes
🇲🇽Aguascalientes, Mexico
Meander Medisch Centrum
🇳🇱Amersfoort, Netherlands
Amsterdam UMC Lokatie VUMC
🇳🇱Amsterdam, Netherlands
Gelre Ziekenhuizen Apeldoorn
🇳🇱Apeldoorn, Netherlands
Reinier de Graaf Gasthuis
🇳🇱Delft, Netherlands
Maxima Medisch Centrum
🇳🇱Eindhoven, Netherlands
Martini Ziekenhuis
🇳🇱Groningen, Netherlands
Bethesda Diabetes Research Center en Bethesda ziekenhuis
🇳🇱Hoogeveen, Netherlands
Spitalul Judetean de Urgenta Targoviste
🇷🇴Targoviste, Dambovita, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures
🇷🇴Targu Mures, Mures, Romania
Sc Mediab Srl
🇷🇴Tirgu Mures, Mures, Romania
Novus Medical Clinica SRL
🇷🇴Ploiesti, Prahova, Romania
CMI Dr. Busegeanu Mihaela Magdalena
🇷🇴Ploiesti, Prahova, Romania
CMI Dr. Pletea Noemi SRL
🇷🇴Bacau, Romania
Diabet Med SRL
🇷🇴Bucharest, Romania
Clinical Emergency Sf. Apostol Andrei Hospital
🇷🇴Galati, Romania
SC Gensan SRL, Policlinica ASTRA
🇷🇴Sibiu, Romania
Tumen State Medical University
🇷🇺Tumen, Russia, Russian Federation
City Hospital #5
🇷🇺Barnaul, Russian Federation
Kazan Federal University
🇷🇺Kazan, Russian Federation
LLC "Clinic of Aesthetic Medicine & Laser Technologies"
🇷🇺Kazan, Russian Federation
SAHI Kuzbass Hospital(former Regional clinical hospital)
🇷🇺Kemerovo, Russian Federation
Friendship University of Russia
🇷🇺Moscow, Russian Federation
Setchenov First Moscow State Medical University
🇷🇺Moscow, Russian Federation
State Novosibirsk regional clinical hospital
🇷🇺Novosibirsk, Russian Federation
Limited Law Company "Healthy Family" Medicine Center"
🇷🇺Novosibirsk, Russian Federation
Penza Regional Clinical Hospital named after N.N. Burdenko
🇷🇺Penza, Russian Federation
Aurora MedFort LLC
🇷🇺Saint Petersburg, Russian Federation
SPb SBHI City Outpatient clinic #37
🇷🇺Saint-Petersburg, Russian Federation
Consultative & Diagnostic Center with a Outpatient Hospital
🇷🇺Saint-Petersburg, Russian Federation
Saratov regional clinical hospital
🇷🇺Saratov, Russian Federation
City Consultative & Diagnostic Centre #1
🇷🇺Saint-Petersburg, Russian Federation
Regional clinical cardiology dispensary
🇷🇺Saratov, Russian Federation
Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
🇷🇸Novi Sad, Vojvodina, Serbia
SPb SBHI City Multifield Hospital #2
🇷🇺St. Petersburg, Russian Federation
Siberian State Medical University
🇷🇺Tomsk, Russian Federation
Ulianovsk Regional Clinical Hospital
🇷🇺Ulianovsk, Russian Federation
Yaroslavl Regional Hospital
🇷🇺Yaroslavl, Russian Federation
Polyclinic #2 in Yoshkar-Ola
🇷🇺Yoshkar-Ola, Russian Federation
CHC Zvezdara, Clinical department for endocrinology
🇷🇸Belgrade, Serbia
Endocrinology, Diabetes and Metabolism Diseases Clinic
🇷🇸Belgrade, Serbia
Military Medical Academy
🇷🇸Belgrade, Serbia
Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department
🇷🇸Kragujevac, Serbia
Clinical Centre Nis, Endocrinology, Diabetes and Metabolism
🇷🇸Nis, Serbia
Policlinic for diabetes
🇷🇸Zajecar, Serbia