Intra-articular Dexmedetomidine for Treatment of Chronic Knee Pain: A Prospective Case-Control Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) post-intra-articular Injection.
研究概览
简要总结
Chronic knee osteoarthritis (KOA) is a painful condition with limited treatment options. Non-pharmacological approaches often fall short, leading to decreased quality of life. Ozone therapy, a simple and affordable treatment, has shown promise for pain relief. Dexmedetomidine (DEX), a sedative and analgesic, has been used successfully as an adjuvant to anesthesia and local anesthetics. Given its potential for pain management, exploring DEX as a treatment for KOA could offer a new and promising approach.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were not assigned for surgical intervention;
- •Patients were free of exclusion criteria
排除标准
- •Patients were assigned for surgical intervention;
- •Patients who had uncontrolled hypertension and/or diabetes mellitus;
- •Patients who had uncompensated cardiac, renal, or hepatic diseases;
- •Patients with coagulopathy, spinal deformity, allergy, or contraindication for the used drugs;
- •Patients who refused to sign the informed consent were excluded from the study.
研究组 & 干预措施
Group 1
A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.
干预措施: Triamcinolone Acetonide (Drug)
Group 1
A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.
干预措施: Bupivacaine Hydrochloride (Drug)
Group 2
A group of Patients from Tanta University suffering from Chronic painful knee osteoarthritis who didn't receive medical treatment and progressed to have chronic pain with decreased physical function and poorer quality of life.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
Proportion of patients reporting at least a 50% reduction in pain (measured by Numerical Rating Scale) post-intra-articular Injection.
时间窗: 7 months
Value of intra-articular Injection in Pain Reduction of chronic knee pain manifested by recurrence of pain.
次要结局
未报告次要终点
研究者
Ahmed ElKashef
lecturer of Anesthesia and Surgical ICU, Faculty of Medicine
Tanta University