Optimization of Perioperative Analgesia with Erector Spinae Plane Block During Major Abdominal Surgeries in Patients with Impaired Liver Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Opioid reduction intraoperatively
Study Overview
Brief Summary
The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant. The main question it aims to answer are Is ESP block safe and has a minimum side effects, like hematoma? Is it effective for perioperative analgesia? Researchers will compare the results to a group of patients who underwent liver transplants without any regional anaesthesia techniques.
Participants will receive bilateral thoracic ESP block on the day of the transplantation with a subsequent bilateral catheterization.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •impaired liver function - cirrhosis or chronic liver disease with the development of hypocoagulation (APTT > 35 sec, INR > 1.5), thrombocytopenia, patients requiring major abdominal surgery, age > 18 years, written consent to participate in the study was obtained
Exclusion Criteria
- •Platelet count <50x109, failed ESP catheterization unilateral or bilateral, failed epidural anesthesia attempt, history of allergy or hypersensitivity to local anesthetics, hepatopulmonary syndrome, patients on mechanical ventilation before surgery, patients on CRRT before surgery, refusal to participate in the study
Arms & Interventions
Liver transplant recipients without regional anesthesia
Liver transplant recipients without regional anesthesia
Liver transplant recipients with regional anesthesia (ESP)
ESP bilateral thoracic with a subsequent catheterization.
Intervention: Erector Spinae Plane Block using 0.2% ropivacaine (Procedure)
Outcomes
Primary Outcomes
Opioid reduction intraoperatively
Time Frame: from enrollment to the end of the operation
The amount of intraoperative fentanyl
Need for opioids postoperatively
Time Frame: from enrollment to the 2nd postoperative day
Need for opioids postoperatively
Pain reduction postoperative
Time Frame: from enrollment to the 2nd postoperative day
Pain assessment with scores
Secondary Outcomes
No secondary outcomes reported
Investigators
Nazarii Mysynchuk
MD
Bogomolets National Medical University