Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

Completed

• Conditions: Chronic Obstructive Pulmonary Disease; Bronchial Asthma; Restrictive Pulmonary Disease

• Registration Number: NCT01762917
• Lead Sponsor: Universitätsmedizin Mannheim

Brief Summary

Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Detailed Description

Not available

Study Timeline

• Study Start: 2007-09
• Primary Completion: 2010-12
• Study Completion: 2010-12
• Study First Submitted: 2012-12-21
• Status Verified: 2013-01
• Study First Submitted QC: 2013-01-07
• Last Update Submitted: 2013-01-07
• Study First Posted: 2013-01-08
• Last Update Posted: 2013-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• ability to perform rebreathing maneuver

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pulmonary blood flow	1 day	variation of serial pulmonary blood flow measurements

Trial Locations

Locations (1)

University Hospital Mannheim; 🇩🇪 Mannheim, Germany