Brain MRI analysis for fibromyalgia patients
Not Applicable
- Conditions
- FibromyalgiaFibromyalgia, MRI
- Registration Number
- JPRN-jRCT1070230082
- Lead Sponsor
- Sasara Takeshi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 26
Inclusion Criteria
(1) Fibromyalgia cases: Diagnosed with Fibromyalgia according to the American College of Rheumatology (ACR) Fibromyalgia criteria (Wolfe et al., 2010), age 18 or older, younger than 75, and right-handed female.
(2) Healthy subjects: Those with no neuropsychiatric medical treatment or history, who scored in the healthy range on the Psychological Stress Response Scale (SRS-18), aged 18 to under 75, right-handed female.
Exclusion Criteria
If contraindications for MRI apply (cardiac pacemaker, cerebral artery clipping surgery, internally implanted devices, etc., pregnant women, etc.)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1)Brain volume: Cortical and subcortical brain volume values for each brain region (mm3), (Anterior cingulate gyrus, Insura cortex, Prefrontal cortes, Hippocampal and Amygdala volume measurement)<br>2)Quantitative measure of nerve fiber bundles Fractional Anisotrophy<br>3)Resting-state functional brain network (connection of emotion-related circuits (correlation coefficient between anterior cingulate gyrus and insular gyrus), connection of descending inhibitory system (anterior cingulate gyrus-central gray matter and ventromedial medulla oblongata) correlation coefficient between parts), default mode network map)
- Secondary Outcome Measures
Name Time Method BPI, Brief Pain Inventory, Japanese version<br>PCS, Pain Catastrophizing Scale, Japanese version<br>PSEQ, Pain Self-Efficacy Questionnaire, Japanese version<br>HADS, Hospital Anxiety and Depression Sale, Japanese version