Long Term Predictors of Acute Myocardial Infarction in Patients With Coronary Revascularization

Completed

• Conditions: Acute Myocardial Infarction; Revascularization

• Registration Number: NCT06546228
• Lead Sponsor: Azienda Ospedaliera Universitaria Policlinico "G. Martino"

Brief Summary

Worldwide, Ischemic heart disease is the single most common fatal disease. One of the most common causes of acute myocardial infarction is represented by obesity. Numerous cardio metabolic variables play a key role in incidence of adverse cardiovascular outcomes. The purpose of this research was to investigate the factors allowing to acute coronary syndrome, related to the metabolic status, to help guide each patient toward early preventing behaviors.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-13
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Study First Submitted: 2024-07-12
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-07
• Last Update Submitted: 2024-08-07
• Study First Posted: 2024-08-09
• Last Update Posted: 2024-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 652

Inclusion Criteria

• Patients met the criteria for Acute Coronary Syndrome (ACS) as defined by the Joint European Society of Cardiology/American College of Cardiology Committee.
• Patients underwent immediate coronary revascularization (primary PCI) for ST-Elevation Myocardial Infarction (STEMI).
• Patients underwent coronary revascularization (early PCI) within 24 hours for Non-ST-Elevation Myocardial Infarction (NSTEMI).
• Patients underwent diagnostic coronary angiography following coronary artery bypass graft surgery (CABG).

Exclusion Criteria

• Known coronary artery disease or previous ACS.
• PCI following CABG.
• Cardiogenic shock.
• Atrial fibrillation.
• Peripheral artery disease.
• Severe cardiac valve disease.
• Prosthetic aorta.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of Acute Myocardial Infarction (AMI)	7 years	Occurrence of AMI. Unit of measure: Medical records, electrocardiogram (ECG), cardiac biomarkers

Secondary Outcome Measures

Name	Time	Method
Change in Left Ventricular Ejection Fraction (LVEF)	7 years	LVEF before and after revascularization Measurement Tool: Echocardiogram Unit of Measure: Percentage (%) change in LVEF
Incidence of Cardiovascular Death	7 years	Occurrence of cardiovascular death Measurement Tool: Medical records Unit of Measure: Number of cardiovascular deaths per patient-year

Trial Locations

Locations (1)

Azienda Ospedaliera Universitaria G. Martino; 🇮🇹 Messina, Italy