COMPARISION OF INTRAVENOUS LIGNOCAINE AND INTRAVENOUS DEXMEDETOMIDINE IN ATTENUATION OF HAEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION IN CONTROLLED HYPERTENSIVE PATIENT
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- To compare the various haemodynamic responses in each group, namely heart rate,systolic blood pressure ,diastolic blood pressure,mean arterial pressure,oxygen saturation
研究概览
简要总结
This is a prospective , double -blind ,randomised control study to be conducted in the operation theatre under the Department of Anaesthesilogy and Critical Care ,GMCH. The study will be carried out on controlled hypertensive adult patients of both sexes , posted for elective surgery. The aim of the study is to compare the efficacy of IV lignocaine and IV dexmedetomidine in attenuation of haemodynamic responses to laryngoscopy and intubation in controlled hypertensive patient. The primary objective is to evaluate the effectiveness of IV lignocaine and IV dexmedetomidine as premedication in attenuating haemodynamic responses in terms of changes in heart rate and mean arterial pressure evoked by laryngoscopy and intubation in controlled hypertensive patients undergoing elective surgeries under general anaesthesia. the secondary objectives are to evaluate the level of sedation and to study any side effects of the drugs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients belonging to age group 18-65 years 2.Patients belonging to ASA grade 2 3.Written and informed consent from the study population.
- •3.Controlled hypertensive patient on anti hypertensive medication.
排除标准
- •1.Patient with heart rate less than 60beats/minutes 2.Patient with systolic blood pressure less than 100mmhg 3.Patient with anticipated difficult intubation 4.Patient with known cardiac disease except hyprtension 5.Patient with history of renal, hepatic,cerebral disease, peripheral vascular disease, pregnant women and lactating mothers 6.History suggestive of sensitivity to drugs used in the study 7.Intubation attempts lasting more than 30seconds 8.Patient who is on beta blocker drugs as anti hypertensive medication.
结局指标
主要结局
To compare the various haemodynamic responses in each group, namely heart rate,systolic blood pressure ,diastolic blood pressure,mean arterial pressure,oxygen saturation
时间窗: Before induction,during intubation, after 1,3,5 and 10 minutes post intubation
次要结局
- 1.To compare the adverse effects (if any)of the drugs studied in each group(2.To evaluate the level of sedation at the time of induction of the patient)
研究者
Popy Borah
Gauhati Medical Collge and Hospital