Evaluation of Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation (a Randomized Controlled Clinical Trial)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Edentulous; Alveolar Process, Atrophy
- Sponsor
- Hams Hamed Abdelrahman
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- change Implant stability
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
melatonin proved an ability to repair bone defects and enhance osseointegration of dental implants. Also, hyaluronic acid has osteopromoting properties.
the effect of melatonin and hyaluronic acid on the newly formed bone in maxillary sinus augmentation was evaluated
Detailed Description
16 participants with missing maxillary posterior teeth and residual alveolar ridge of at least 5 mm will be equally and randomly divided into two groups. The study group will receive melatonin and hyaluronic acid after sinus membrane elevation and simultaneous implant placement while the control group will not receive any materials after sinus membrane elevation and simultaneous implant placement.
Investigators
Hams Hamed Abdelrahman
Assistant lecturer of DPH and Clinical statistician
Alexandria University
Eligibility Criteria
Inclusion Criteria
- •Age range will be between (30 - 50) years old.
- •Patients with missed one or more of posterior teeth with minimum residual bone height 5 mm
- •Adequate inter-occlusal space of at least 8 mm
Exclusion Criteria
- •Maxillary sinus diseases.
- •Previous sinus surgery like the Caldwell-Luc operation.
- •History of chemotherapy or radiotherapy to maxilla.
- •Presence of Underwood's septa/severe sinus floor convolutions.
- •Systemic disease affecting bone metabolism.
- •Uncontrolled diabetes mellitus.
- •Heavy smokers.
- •Para functional habits.
Outcomes
Primary Outcomes
change Implant stability
Time Frame: at baseline and 6 months
The result is presented as an ISQ value of 1-100. The acceptable stability range lies between 55-85 ISQ. The higher the ISQ, the more stable the implant
change in bone density
Time Frame: at baseline, 1 month and 6 months
radiographical evaluation using CBCT
change in vertical bone height
Time Frame: at baseline, 1 month and 6 months
radiographical evaluation using CBCT
change in marginal bone level
Time Frame: at baseline, 1 month and 6 months
radiographical evaluation using CBCT
Secondary Outcomes
- Postoperative pain(after 1 week)
- Postoperative swelling(after 1 week)