Impact of Differential and Systematic Dengue, Chikungunya, and Malaria Diagnostics on Patient Management and Antibiotic Use in Burkina Faso and Ivory Coast
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- BioMérieux
- 入组人数
- 804
- 试验地点
- 3
- 主要终点
- Rate of antibiotic prescription
研究概览
简要总结
The differential and systematic diagnosis of malaria, dengue and chikungunya in patients with fever (≥38.5°C) of undetermined etiology would allow the identification of infection by these pathogens and thus limit the inappropriate use of antibiotics (discontinuation or non-initiation) and optimize the clinical management and prognosis of patients.
详细描述
The research hypotheses are as follows:
- Systematic diagnosis of malaria, dengue and chikungunya using diagnostic tests would improve the clinical management of patients with fever of undetermined etiology and reduce the misuse of antibiotics (discontinuation or non-initiation) and associated resistance.
- Improved management is associated with a reduction in the use of hospital resources, professional inactivity and an improvement in the quality of life and satisfaction of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects aged ≥ 18 years
- •Patient with fever (≥38.5°C) and at least two of the following symptoms in the last 10 days:
- •Severe headache
- •Retro-orbital pain
- •Muscle and joint pain
- •Adenopathy
- •Abdominal pain
- •Spontaneous bleeding (purpura, epistaxis, haematemesis, etc)
- •Willingness and ability to provide two 4 mL blood samples
- •Willingness to provide one drop of blood per capillary sample
- •Informed and signed consent
排除标准
- •Subjects aged < 18 years
- •Pregnant women
- •Breastfeeding women
- •Patient's refusal to participate in the study
研究组 & 干预措施
Intervention Site
In the interventional sites, bioMérieux teams provided training to raise awareness of the diagnosis of dengue, chikungunya and malaria. In addition, a VIDAS instrument was installed and dengue and chikungunya diagnostic kits were supplied so that diagnosis could be carried out systematically for each patient included.
干预措施: VIDAS® Dengue Antigen NS1, VIDAS® Anti-Dengue IgM, VIDAS® Anti-Dengue IgG, VIDAS® Anti-Chikungunya IgM and VIDAS® Anti-Chikungunya IgG (Diagnostic Test)
Control Site
In the control centres, only routine practices were observed.
干预措施: Standard of care practices (Other)
结局指标
主要结局
Rate of antibiotic prescription
时间窗: Inclusion and Day 7
Rate of antibiotic prescription (discontinuation or non-initiation).
次要结局
- Consumption of hospital resources(Day 7)
- Patient's loss of productivity(Inclusion and Day 7)
- Patient's quality of life(Inclusion and Day 7)
- Patient satisfaction(Inclusion and Day 7)