EUCTR2019-000709-55-BE进行中（未招募）1 期
Sugammadex dose-finding study for reversal of deep rocuronium-induced neuromuscular block
niversitair Ziekenhuis Brussel0 个研究点目标入组 60 人开始时间: 2020年1月13日最近更新:
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •- Patients scheduled to undergo elective maxillofacial surgical procedures with an expected duration of general anaesthesia of more than one hour
- •- 18–65 years
- •- body mass index 18.5–25.0 kg/m²
- •- ASA I–II
- •- general anesthesia with naso- or orotracheal intubation requiring only deep neuromusculair block (NMB) for the intubation procedure.
- •- Male-to-female allocation ratio 1:1 was respected at patient selection.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 60
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •- suspected difficult airway
- •- bronchial asthma
- •- chronic obstructive pulmonary disease
- •- neuromuscular disease
- •- suspected malignant hyperthermia
- •- significant hepatic or renal dysfunction
- •- glaucoma
- •- allergy to the drugs used in this trial, and taking medication known to influence the effect of NMBAs.
- •- Patients who participated in another study in =1 month will not be included
- •- pregnant or breastfeeding patients.
- •The following medications are known to interact with NMB (neuromuscular blocker):
- •-Tetracyclines, aminoglycosides, polymyxins, and clindamycin potentiate neuromuscular blockade through inhibition of acetylcholine (ACh) release or desensitization of postjunctional nAChRs to ACh
- •-Patients receiving chronic treatment of anti-epileptic drugs are relatively resistant to nondepolarizing NMBAs due to accelerated clearance of these drugs
- •-Patients who take lithium can have a prolonged response to both depolarizing and nondepolarizing NMBAs
- •-In laboratory studies, sertraline and amitriptyline inhibit butyrylcholinesterase
- •-Local anesthetics (LAs) may enhance the effects of both depolarizing and nondepolarizing NMBAs through pre- and post-synaptic interactions at the neuromuscular junction (NMJ) Data on the effects of lidocaine on neuromuscular block are conflicting. Whereas one study reported that epidural lidocaine potentiated vecuronium-induced neuromuscular block , several studies have reported no effect of intravenous (IV) lidocaine on the onset, duration, or recovery from rocuronium-induced neuromuscular block ,
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