Effects of Meal Fatty Acid Composition on Postprandial Lipaemia in Men According to APOE Genotype
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Impact of APOE genotype and dietary fat composition in plasma lipids
研究概览
简要总结
Cardiovascular disease (CVD) is the greatest cause of morbidity and mortality in the UK. Abnormalities in the concentration and/or composition of lipoproteins (the lipid carrying particles), in particular low density lipoproteins (LDL) in circulation, is one of the most important physiological defects contributing to the development of CVD.
The LDL cholesterol (LDLC) response to fatty acid change is in part mediated by the APOE genotype, with E4 individuals (25% of the UK population) being most responsive to changes in dietary fats, showing greater reductions when low levels of saturated fats or fish oils are consumed and greater increases when high levels of these fats are consumed. Therefore the aims of the present study is to understand the mechanism that regulates the higher LDLC response associated with saturated fatty acids and fish oil consumption in healthy men prospectively recruited based on their APOE genotype.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Gender Male
- •Age 18-70 years
- •Body Mass Index (BMI) < 32 kg/m2
- •Plasma triglycerides 1-4 mmol/l
- •Plasma cholesterol < 8 mmol/l
- •Glucose < 7 mmol/l
- •Haemoglobin > 11 g/dl
- •ApoE E3/E3, E3/E4
排除标准
- •Blood pressure > 200/95 mmHg
- •Had suffered a myocardial infraction or stroke in previous 2 years.
- •Diabetes mellitus
- •Liver disease
- •Other endocrine disorders
- •Unstable angina
- •Familial hyperlipidaemia
- •Any dietary restrictions or an a weight reducing diet
- •On fatty acid supplements e.g. evening primrose oil or fish oils
- •Vigorous exercise e.g. competitive athletes
- •ApoE2/E2, apoE2/E3 and apoE2/E4
- •Any other parameter on which the investigators felt an individual was unsuitable
研究组 & 干预措施
High unsaturated fat meal
Provided a fatty acid profile representative of a typical UK diet
干预措施: High unsaturated fat meal (Dietary Supplement)
High saturated fat meal
干预措施: High saturated fat meal (Dietary Supplement)
Saturated fatty acid and fish oils meal
Equivalent to two portions of oily fish
干预措施: Saturated fatty acids and fish oil meal (Dietary Supplement)
结局指标
主要结局
Impact of APOE genotype and dietary fat composition in plasma lipids
时间窗: 3 months
次要结局
- Cardiovascular disease risk factors(3 months)
研究者
Julie Lovegrove
Professor
University of Reading