A Prospective, open labelled, single arm, non randomized, single centric, phase II, Clinical trail to determine the effectiveness of Poora Maathirai in the management of Uthiravatha suronitham (Rheumatoid arthritis)

This is A Prospective, open labelled, single arm, non randomized, single centric, phase II, Clinical trail to determine the effectiveness of Poora Maathirai in the management of Uthiravatha suronitham (Rheumatoid arthiritis). After purification of trial drugs,  Poora maathirai will be prepared and administered at the dosage of 1 to 2 tablets for 48 days for 40 Rheumatoid Arthritis patients ( 20 OP and 20 IP Patients). The primary outcome will be to evaluate the therapeutic effectiveness  of  Siddha herbal Poora Maathirai in the management of Uthiravatha suronitham(Rheumatoid arthritis).The secondary outcome will be to collect various Siddha literatures and modern journals for literature review of Uthiravatha suronitham, to perform physicochemical, phytochemical, bio chemical analysis of Poora Maathirai, to evaluate safety profile for acute and sub-acute toxicity of -Poora Maathirai, to evaluate pharmacological activities of Poora maathirai, to study other cofactors related to disease like age, sex, dietary habits, family history, and socioeconomic status, to study about the prevalence of Uthiravatha suronitham relation with diet and lifestyleto evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri) for Uthiravatha suronitham during trial period, to evaluate Dhegi of Uthiravatha suronitham patients, to evaluate modern parametric changes in Uthiravathasuronitham, to assess the quality of life  of Uthiravatha suronitham  patients, to document Bio statistical analysis.