Azathioprine effect in severe asthmatic patients

Phase 3

• Conditions: Asthma.; Severe persistent asthma; J45.5

• Registration Number: IRCT20231219060463N1
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Severe asthmatic patients (FEV1<60) diagnosed by pulmonologist
No improvement in symptoms with usual treatments for asthma including Prednisolone 5mg/day, High dose inhaled corticosteroid, Long acting beta agonist and Long acting muscarinic antagonist

Exclusion Criteria

Advanced liver failure
Advanced renal failure
Pregnancy
Breastfeeding
Cytopenia
Moderate to severe anemia
Known allergy to azathioprine
Concomitant treatment with: Allopurinol, Febuxostat, Adalimumab, Anakinra
Elevated liver enzymes (aminasemia)

Study & Design

• Study Type: interventional
• Study Design: Not specified