Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

Not Applicable

Completed

• Conditions: Aphasia; Stroke; Dyslexia, Acquired
• Interventions: Behavioral: One-on-one treatment of reading difficulties

• Registration Number: NCT00827268
• Lead Sponsor: VA Office of Research and Development

Brief Summary

This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.

Detailed Description

The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated across up to 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal includes the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment.

Study Timeline

• Study First Submitted: 2009-01-20
• Study First Submitted QC: 2009-01-21
• Study First Posted: 2009-01-22
• Study Start: 2009-06
• Primary Completion: 2011-12
• Study Completion: 2012-07
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-28
• Last Update Posted: 2017-11-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

• Adults with post-stroke reading difficulties (phonological alexia)
• >3 months post-stroke
• native English speaker
• can go in MRI scanner (3 to 6 scans),
• participate in 90 to 120 free treatment sessions
• return for 3-month post-treatment follow-up assessment & MRI.

Exclusion Criteria

• mental illness
• degenerative disease, visual or auditory acuity impairment
• drug abuse
• English is not first language
• claustrophobia
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Arm 1	One-on-one treatment of reading difficulties	Repeated probes every 8 hours of treatment (1/week)

Primary Outcome Measures

Name	Time	Method
Change in Real World Reading Skills	Language testing are conducted two weeks prior to treatment, immediately following end of treatment and 3 months after end of treatment.	Real World Reading Skills was tested using the Woodcock Reading Mastery Test-Revised

Trial Locations

Locations (1)

North Florida/South Georgia Veterans Health System; 🇺🇸 Gainesville, Florida, United States