The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Bangor University
- Enrollment
- 23
- Locations
- 2
- Primary Endpoint
- Acute Mountain Sickness (AMS-C) as Assessed by the Environmental Symptoms Questionnaire.
Study Overview
Brief Summary
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment. It is hypothesized that beetroot supplementation will decrease acute mountain sickness and increase exercise performance.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Women only: Regular menstrual cycle or post-menopausal
Exclusion Criteria
- •Stayed at altitude above 2500m in the last 6 months
- •Traveled to altitude above 2500m in the last 2 months
- •Unable to give informed consent
- •Unstable medical condition.
Outcomes
Primary Outcomes
Acute Mountain Sickness (AMS-C) as Assessed by the Environmental Symptoms Questionnaire.
Time Frame: Measured on the fifth day of supplementation with a six-hour exposure to hypoxia
Acute Cerebral Mountain Sickness score (AMS-C) calculated from the 11-item Environmental Symptoms Questionnaire (ESQ; Sampson et al., 1994). Participants rate the severity of each item from zero to five, and the ratings were multiplied by their factorial loadings and summed. Unabbreviated scale title: Acute Cerebral Mountain Sickness Abbreviated title: AMS-C Unit of measure: Scores on a scale Minimum value: 0 Maximum value: 5 Interpretation: Higher scores mean a worse outcome
Secondary Outcomes
- Hypoxic Exercise Performance as Assessed by Time to Exhaustion at 80% of Hypoxic V̇O2max Reserve.(Measured on the sixth day of supplementation)