To assess the effect of Dexmedetomidine drug on postoperative renal function in patients undergoing valve surgery
Phase 2
- Conditions
- Health Condition 1: I08- Multiple valve diseases
- Registration Number
- CTRI/2024/05/067338
- Lead Sponsor
- SMS Medical College and Hospitals
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients willing to give consent.
2. Patients of 18 to 80 years of age scheduled for cardiac valve replacement/valvuloplasty with either a single valve or multiple valves under CPB.
3. ASA grade 2 and 3.
Exclusion Criteria
1.Non-cooperative patient.
2.Patients with BMI more than or equals to 30kg/m2.
3. Patients with pre-op pulmonary infection, liver insufficiency, kidney insufficiency.
4. Patients with history of use of nephrotoxic drugs and contrast agents used within 48 hours.
5. Patients with history of kidney or heart surgery.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of Mean changes in renal function pre-op and post op 48 hrs after surgery by measuring Serum Creatinine and Blood Urea.Timepoint: Comparison of Mean changes in renal function pre-op and post op 48 hrs after surgery by measuring Serum Creatinine and Blood Urea.
- Secondary Outcome Measures
Name Time Method 1.Comparison of Mean changes in Intraoperative Haemodynamics (MAP and HR). <br/ ><br>2.Comparison of Mean Changes in serum indices C reactive protein levels in both the groups. <br/ ><br>3.Comparison of Mean Changes in postoperative recovery and incidence of complications.Timepoint: 1.30min interval throughout surgery. <br/ ><br> <br/ ><br>2.48 to 72 hours after surgery.