Novelty, Conformity and Trust in Vaccines
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35,180
- 试验地点
- 2
- 主要终点
- Belief in how much COVID-19 vaccine should be subsidized by the government
研究概览
简要总结
Despite their established benefits as public measures, vaccines continue to be treated with suspicion by many people, in the US and other parts of the world (Larson et al. 2014; Olive et al. 2018; Lazarus et al. 2020). Since the success of vaccines depends on their high uptake level (Anderson and May, 1985; Fine et al. 2011; Fontanet and Cauchemez, 2020), identifying factors that influence low trust and decision-making in relation to vaccines is essential in order to combat diseases such as the novel Coronavirus (COVID-19).
The investigators study factors that could potentially influence public's trust in COVID-19 vaccines through a large-scale online field experiment. The investigators conduct an online survey of 32,400 subjects in nine countries (USA, Brazil, Mexico, China, India, Indonesia, Russia, Germany, and UK).
The investigators study how willingness to receive the COVID-19 vaccine is affected by (1) the "novelty" of the vaccine technology (conventional vs. RNA vaccines), and (2) the adoption rate of the new vaccine in the country. That is - the impact of controversial science and the force of conformity on the rates of adoption. The latter will also allow us to calculate the "tipping point" adoption rate for each country that will allow the country to achieve herd immunity from COVID-19.
The investigators have four hypotheses, below.
H1 (Conformity): People are more willing to receive a vaccine as the cumulative adoption rate in their community increases.
H2 (Novelty): People are less willing to get a COVID-19 vaccine that uses the new RNA technology, compared to a conventional vaccine
H3 (Interaction between H1 and H2): As the cumulative adoption rate in a community increases, the difference between people's willingness to adopt conventional rather than RNA vaccines decreases.
H4 (Tipping Point): Each country will have a different "tipping point". This is the cumulative adoption rate after which unvaccinated people are significantly more willing to get the vaccine. Countries that have a higher "honesty index" will have the tipping point appear at a lower cumulative adoption rate.
Please note that this study is not a clinical trial. This study is a randomized controlled trial in the form of an online survey.
详细描述
The investigators study the role of trust in COVID-19 vaccine through a global survey. Specifically, the investigators vary (1) the degree of vaccine innovation and (2) the adoption rate of the vaccine to test if these factors influence the individuals' willingness to receive the vaccine.
An online survey is conducted across 9 countries with 3,600 subjects per country. About 15 questions will be asked for each subject and the survey is expected to take about 10-15 minutes to complete.
The 9 countries are USA, Brazil, Mexico, China, India, Indonesia, Russia, Germany and the UK. The three most populous countries from three major continents (Americas, Asia and Europe) are chosen. The target subjects are healthy adults over 18 years of age.
The survey instrument will consist of two parts. In the first part, the survey will ask 10 questions regarding their demographics and the general perception on the safety, effectiveness, and importance of vaccines. This part of the survey allows us to explore the relationship between the individual factors (such as age, gender or income status) and trust in COVID-19 vaccine, as well as to normalize the attitude towards COVID-19 vaccines over the overall vaccine-related confidence.
The 3 key questions of interest are:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults over 18 years old
排除标准
- 未提供
结局指标
主要结局
Belief in how much COVID-19 vaccine should be subsidized by the government
时间窗: During the 15-minute survey
Subjects' response to the question: "How much do you think the government should subsidize the conventional COVID-19 vaccine?" There are 5 answer options: 0%, 25%, 50%, 75%, 100%.
Willingness to receive COVID-19 vaccine
时间窗: During the 15-minute survey
Subjects' response to the question: "If the conventional COVID-19 vaccine were provided to you for free, how likely are you to accept the vaccination?" on a Likert scale from 1 (very unlikely) to 5 (very likely).
次要结局
- Belief in effectiveness of vaccines(During the 15-minute survey)
- Dishonesty index(During the 15-minute survey)
- Belief in importance of vaccinating children(During the 15-minute survey)
- Belief in safety of vaccines(During the 15-minute survey)
研究者
Ho Teck Hua
Director
National University of Singapore