Pilot Study of Myocardial Effects Following an Endurance Race

Not Applicable

• Conditions: Myocardial Blood Flow
• Interventions: Behavioral: Endurance Race

• Registration Number: NCT03549364
• Lead Sponsor: University Hospital, Linkoeping

Brief Summary

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests for myocardial injury and inflammation.

The same data are collected \<24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow.

Detailed Description

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests (troponin T, hs-CRP, CK-mb etc) for myocardial injury and inflammation.

The same data are collected \<24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging (MRI) is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow. The CT of the heart includes contrast injection and blood flow will be determined by a recently developed based on very powerful computers using "machine learning".

Study Timeline

• Study First Submitted: 2018-05-11
• Study Start: 2018-05-24
• Study First Submitted QC: 2018-05-24
• Study First Posted: 2018-06-08
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-23
• Last Update Posted: 2019-04-24
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Healthy subjects, experienced in long distance running

Exclusion Criteria

Significant renal, kidney, heart, liver or musculoskeletal disease.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Endurance race	Endurance Race	1. baseline investigations with CT and lab tests 2. the same CT and lab tests \< 24h after an endurance race 3. CT and lab tests again about 1-2weeks after the race

Primary Outcome Measures

Name	Time	Method
Change in myocardial blood flow by the race?	All investigations are performed < 2 months	Detection of potential differences in blood flow between occasion 1 and 2 and 3

Trial Locations

Locations (1)

University Hospital of Linkoping; 🇸🇪 Linkoping, Sweden